Stephanie Metcalfe

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BACKGROUND Human leukocyte antigen (HLA) alleles code for proteins that are involved in the recognition of foreign antigens and activation of the immune system. The frequency of HLA alleles varies across different populations. OBJECTIVE To describe the frequency of HLA alleles in a population of Inuit women of Nunavik, Quebec, Canada. DESIGN A cohort of(More)
PURPOSE To report the outcomes of a population of women with ductal carcinoma in situ (DCIS) treated with breast-conserving surgery and radiation and to evaluate the independent effect of boost radiation on the development of local recurrence. METHODS AND MATERIALS All women diagnosed with DCIS and treated with breast-conserving surgery and radiation(More)
BACKGROUND The human leukocyte antigen (HLA)-G molecules act as negative regulators of the immune response. We analyzed the associations between HLA G polymorphisms and human papillomavirus (HPV) infection and squamous intraepithelial lesions (SIL) in Inuit women from Nunavik, northern Quebec. METHODS Cervical specimens from a cohort study of 548 Inuit(More)
Aerobic and anaerobic culture of sputum on selective bacteriological media, combined with a new method of plating and plate reading, permitted rapid identification and quantitation of three genera of bacteria commonly associated with chronic bronchial sepsis (Haemophilus spp, Pseudomonas aeruginosa, and Staphylococcus aureus) and avoided time consuming(More)
In haemagglutination tests we have found that the monoclonal antibody B5 discriminates between erythrocytes from patients with malignant cancer (total 386; greater than 80% B5 positive) and individuals with no known tumour (total 247; less than 20% B5 positive). The B5 antigen detected on intact erythrocytes is a tightly bound surface component which does(More)
The recent dramatic success in the treatment of testicular cancer is due to advances in patient management involving computerised tomography, effective combination chemotherapy, and accurate measurement of the biochemical markers a-foetoprotein (a-FP) and ,B subunit of human gonadotrophin (#HCG) (Ellis & Sikora, 1984). These two proteins are abnormally high(More)
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