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  • Shao Jie Wei, Andrés Jaramillo Botero, +7 authors David R. Gius
  • Biology, Medicine
  • Cancer research
  • 2000 (First Publication: 1 December 2000)
  • Thioredoxin (TRX) is a cytoplasmic, redox-sensitive signaling factor believed to participate in the regulation of nuclear transcription factors mediating cellular responses to environmental stress.Continue Reading
  • Kheem S. Bisht, C. Matthew Bradbury, +10 authors David R. Gius
  • Biology, Medicine
  • Cancer research
  • 2003 (First Publication: 15 December 2003)
  • Ansamycin antibiotics inhibit function of the heat shock protein (HSP) 90, causing selective degradation of several intracellular proteins regulating such processes as proliferation, cell cycleContinue Reading
  • Shervin Karimpour, Junyang Lou, +12 authors David R. Gius
  • Biology, Medicine
  • Oncogene
  • 2002 (First Publication: 1 September 2002)
  • A recently identified class of signaling factors uses critical cysteine motif(s) that act as redox-sensitive ‘sulfhydryl switches’ to reversibly modulate specific signal transduction cascadesContinue Reading
  • Natalie Scott Callander, Stephanie Markovina, +9 authors Shigeki Miyamoto
  • Medicine
  • Cancer Chemotherapy and Pharmacology
  • 2014 (First Publication: 1 October 2014)
  • PurposeRetreatment with bortezomib (B) is often considered for patients with relapsed multiple myeloma (MM), but this strategy is hindered by uncertainty of response and emergence of B-inducedContinue Reading
  • Stephanie Markovina, Marshall W Meeks, +5 authors Gurdarshan S. Sandhu
  • Medicine
  • Advances in radiation oncology
  • 2018 (First Publication: 1 December 2017)
  • Purpose For high-risk prostate cancer (HR-PCa) in men with a life expectancy of at least 10 years, the National Comprehensive Cancer Network recommends radiation therapy (RT) plus androgenContinue Reading