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Action in the axon: generation and transport of signaling endosomes
Neurons extend axonal processes over long distances, necessitating efficient transport mechanisms to convey target-derived neurotrophic survival signals from remote distal axons to cell bodies.Expand
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GGA1 Acts as a Spatial Switch Altering Amyloid Precursor Protein Trafficking and Processing
The β-amyloid (Aβ) precursor protein (APP) is cleaved sequentially by β-site of APP-cleaving enzyme (BACE) and γ-secretase to release the Aβ peptides that accumulate in plaques in Alzheimer's diseaseExpand
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Sensory Neuropathy Attributable to Loss of Bcl-w
Small fiber sensory neuropathy is a common disorder in which progressive degeneration of small-diameter nociceptors causes decreased sensitivity to thermal stimuli and painful sensations in theExpand
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A Retrograde Neuronal Survival Response: Target-Derived Neurotrophins Regulate MEF2D and bcl-w
Survival and maturation of dorsal root ganglia sensory neurons during development depend on target-derived neurotrophins. These target-derived signals must be transmitted across long distances toExpand
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Neuromuscular Junction Defects in Mice with Mutation of dynein heavy chain 1
Disruptions in axonal transport have been implicated in a wide range of neurodegenerative diseases. Cramping 1 (Cra1/+) and Legs at odd angles (Loa/+) mice, with hypomorphic mutations in the dyneinExpand
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Clientèles difficiles dans les bibliothèques de Montréal: témoignages sur la réalité des employés
EnglishPublic libraries have the mission to allow access to a maximum amount of people, without discrimination. This has the effect of diversifying the patron base and, consequently, allows access toExpand