Clinical observations and animal studies have raised the hypothesis that increased concentrations of manganese (Mn) in whole blood might lead to accumulation of this metal within the basal ganglia in… (More)
We have taxonomically and phylogenetically characterized a new aerobic bacterial strain (JF-1) that contains photosynthetic pigment-protein complexes and which was recently isolated from black smoker… (More)
OBJECTIVE
To investigate the effects of the cartilage-derived morphogenetic proteins (CDMPs) in an in vitro cartilage explant model that mimics the chondrocytic response to matrix depletion, and to… (More)
Background:Many cancers spread through lymphatic routes, and mechanistic insights of tumour intravasation into the lymphatic vasculature and targets for intervention are limited. The major emphasis… (More)
OBJECTIVE
To compare the impact of sertindole and haloperidol on cognitive function in patients suffering from schizophrenia.
METHODS
In a 12 week trial, of the 40 patients randomised to treatment,… (More)
In Kinetoplastida, trypanothione and trypanothione reductase (TRYR) provide an intracellular reducing environment, substituting for the glutathione-glutathione reductase system found in most other… (More)
BACKGROUND/AIMS
Deterioration of hepatic encephalopathy is a major concern with the transjugular intrahepatic portosystemic shunt procedure. Symmetric hyperintense globus pallidus on T1-weighted… (More)
CONTEXT
Animal data suggest that adverse early experiences may affect endocrine and immune functioning in later life.
OBJECTIVE
Our objective was to assess the impact of preterm delivery on… (More)
Background:As metastasis is the prime cause of death from malignancies, there is vibrant interest to discover options for the management of the different mechanistic steps of tumour spreading. Some… (More)
BACKGROUND
Many unclassified variants (UV) of BRCA1 or BRCA2 may have an effect on pre-mRNA splicing. Patient blood samples suitable for RNA extraction are not always available for testing UVs at the… (More)