Stephanie J. Thomas

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PURPOSE We are in great need of specific biomarkers to detect pancreatic ductal adenocarcinoma (PDAC) at an early stage, ideally before invasion. Plectin-1 (Plec1) was recently identified as one such biomarker. However, its suitability as a specific biomarker for human pancreatic cancer, and its usability as an imaging target, remain to be assessed. (More)
Molecular imaging allows clinicians to visualize the progression of tumours and obtain relevant information for patient diagnosis and treatment. Owing to their intrinsic optical, electrical and magnetic properties, nanoparticles are promising contrast agents for imaging dynamic molecular and cellular processes such as protein-protein interactions, enzyme(More)
Pancreatic ductal adenocarcinoma (PDAC) is highly malignant disease that is the fourth leading cause of cancer-related death in the US. Gene therapy using AAV vectors to selectively deliver genes to PDAC cells is an attractive treatment option for pancreatic cancer. However, most AAV serotypes display a broad spectrum of tissue tropism and none of the(More)
UNLABELLED The inability to successfully treat women with ovarian cancer is due in large part to the advanced stage of disease at diagnosis, the development of platinum resistance, and the lack of sensitive methods to monitor tumor progression and response to treatment. Vascular cell adhesion molecule-1 (VCAM-1) is expressed on the mesothelium of ovarian(More)
In recent years, formation flying has been recognized as an enabling technology for a variety of mission concepts in both the scientific and defense arenas. Examples of developing missions at NASA include magnetospheric multiscale (MMS), solar imaging radio array (SIRA), and terrestrial planet finder (TPF). For each of these missions, a multiple satellite(More)
Space debris is a rising concern for the sustained operation of our satellites. The population in space is continually growing, both gradually with a steady stream of new launches, and in sudden bursts, as evidenced with the recent collision between the Iridium and inactive COSMOS spacecraft. The problem is most severe in densely populated orbit regimes,(More)
PRISMA will demonstrate Guidance, Navigation, and Control strategies for advanced autonomous formation flying. The Swedish Space Corporation (SSC) is the prime contractor for the project which is funded by the Swedish National Space Board (SNSB). The mission consists of two spacecraft: MAIN and TARGET. The MAIN satellite has full orbit control capability(More)
Manned spacecraft will require maintenance robots to inspect and repair components of the spacecraft that are only accessible from the outside. This paper presents a design of a novel free-flying maintenance robot (known as a MaintenanceBot.) The MaintenanceBot uses Control Moment Gyros (CMGs) for manipulator arm and attitude control. This provides high(More)
Prostate cancer is the most commonly diagnosed non-skin malignancy in the United States and presents with a wide range of aggressiveness from extremely slow-growing to highly aggressive. There is a clinical need to determine the metastatic potential of the primary tumor to design the most appropriate treatment plan ranging from watchful waiting to more(More)
A MATLAB-based software tool, called the Solar Sail Control Toolbox, has been developed for solar sail analysis, design and simulation. The toolbox includes functions for multibody dynamic modeling, attitude control systems design, thrust vector control design, orbit analysis, solar sail mission analysis, thermal analysis and power subsystem analysis.(More)