Stephanie J. DeWitte-Orr

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Extracellular RNA is becoming increasingly recognized as a signaling molecule. Virally derived double stranded (ds)RNA released into the extracellular space during virus induced cell lysis acts as a powerful inducer of classical type I interferon (IFN) responses; however, the receptor that mediates this response has not been identified. Class A scavenger(More)
Viruses produce nucleic acids during their replication, either during genomic replication or transcription. These nucleic acids are present in the cytoplasm or endosome of an infected cell, or in the extracellular space to be sensed by neighboring cells during lytic infections. Cells have mechanisms of sensing virus-generated nucleic acids; these nucleic(More)
The baculovirus insect cell protein expression system has been used widely for over 25 years to produce recombinant proteins. Cervarix®, a vaccine for the prevention of cervical cancer, produced in this system was approved for clinical use by the FDA in 2009. More recently baculoviruses modified to express recombinant proteins in transduced mam-malian cells(More)
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