• Publications
  • Influence
Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+ cells as homologues of mouse CD8+ dendritic cells
TLDR
It is shown that CD141+ DCs are the only cells in human blood that express the chemokine receptor XCR1 and respond to the specific ligand XCL1 by Ca2+ mobilization and potent chemotaxis and defined as professional antigen cross-presenting DCs in the human. Expand
Expression of XCR1 Characterizes the Batf3-Dependent Lineage of Dendritic Cells Capable of Antigen Cross-Presentation
TLDR
XCR1 emerges as the first surface marker characterizing a DC lineage in the mouse and potentially also in the human, and it is demonstrated that XCR1+ DCs in the spleen, LNs, and peripheral tissues are dependent on the growth factor Flt3 ligand and are selectively absent in Batf3-deficient animals. Expand
Induction of Potent CD8 T Cell Cytotoxicity by Specific Targeting of Antigen to Cross-Presenting Dendritic Cells In Vivo via Murine or Human XCR1
TLDR
The specificity and efficiency of XCR1-mediated Ag targeting to cross-presenting DC, combined with its lack of adverse effects, make this system a prime candidate for the development of therapeutic cytotoxic vaccines in humans. Expand
Local T/B cooperation in inflamed tissues is supported by T follicular helper-like cells
TLDR
The importance of T/B cooperation not only in lymph nodes but also in inflamed peripheral tissues for local antibody responses to infection and autoimmunity is shown. Expand
Mouse Conventional Dendritic Cells Can be Universally Classified Based on the Mutually Exclusive Expression of XCR1 and SIRPα
TLDR
It is demonstrated in the present article that all conventional DC in the mouse can be universally subdivided into either XCR1+ (“cross-presenting”) DC or SIRPα+ DC, irrespective of their activation status. Expand
Ontogenic, Phenotypic, and Functional Characterization of XCR1+ Dendritic Cells Leads to a Consistent Classification of Intestinal Dendritic Cells Based on the Expression of XCR1 and SIRPα
TLDR
Evidence is provided that intestinal XCR1+ DC largely, but not fully, overlap with CD103+ CD11b− DC, the hypothesized correlate of “cross-presenting DC” in the intestine, and are selectively dependent in their development on the transcription factor Batf3. Expand
Comprehensive Analysis of CD4+ T Cells in the Decision between Tolerance and Immunity In Vivo Reveals a Pivotal Role for ICOS
TLDR
Given its exceptionally selective induction on CD4+ T cells under inflammatory, but not tolerogenic, conditions, ICOS emerges as a pivotal effector molecule in the early decision between tolerance and immunity to exogenous Ag. Expand
Expression analysis of surface molecules on human thymic dendritic cells with the 10th HLDA Workshop antibody panel
TLDR
This work studied the binding of 71 monoclonal antibodies submitted to the HLDA10 workshop to human CD123+ plasmacytoid DC and the two subsets of conventional DC isolated from thymus tissue of infants undergoing corrective heart surgery. Expand
Ontogenic, phenotypic, and functional characterization of XCR1+ dendritic cells leads to a consistent classification of intestinal dendritic cells based on the expression of XCR1 and SIRPα
TLDR
Evidence is provided that intestinal XCR1+ DC largely, but not fully, overlap with CD103+ CD11b- DC, the hypothesized correlate of “cross-presenting DC” in the intestine, and are selectively dependent in their development on the transcription factor Batf3. Expand
Mouse conventional dendritic cells can be universally classified based on the mutually exclusive expression of XCR1 and SIRPα
TLDR
It is demonstrated in the present article that all conventional DC in the mouse can be universally subdivided into either XCR1+ cross-presenting DC or SIRPα+ DC, irrespective of their activation status. Expand
...
1
2
...