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Imprinted genes are expressed primarily or exclusively from either the maternal or paternal allele, a phenomenon that occurs in flowering plants and mammals. Flowering plant imprinted gene expression has been described primarily in endosperm, a terminal nutritive tissue consumed by the embryo during seed development or after germination. Imprinted(More)
IMPORTANCE Several randomized clinical trials have demonstrated the efficacy of preexposure prophylaxis (PrEP) in preventing human immunodeficiency virus (HIV) acquisition. Little is known about adherence to the regimen, sexual practices, and overall effectiveness when PrEP is implemented in clinics that treat sexually transmitted infections (STIs) and(More)
PURPOSE To evaluate the rate of positive, negative, and indeterminate results and the agreement between initial and expert readings for lung scintigraphy and computed tomographic (CT) angiography performed in patients suspected of having pulmonary embolism (PE) during pregnancy. MATERIALS AND METHODS Institutional review board approval was obtained. The(More)
BACKGROUND Preexposure prophylaxis (PrEP) is the first biomedical intervention with proven efficacy to reduce HIV acquisition in men who have sex with men (MSM) and transgender women. Little is known about levels of interest and characteristics of individuals who elect to take PrEP in real-world clinical settings. METHODS The US PrEP Demonstration Project(More)
OBJECTIVES Diabetes mellitus (DM) has been associated with an increased risk of colorectal cancer (CRC). The American College of Gastroenterology Guidelines for Colorectal Cancer Screening 2008 recommend that clinicians be aware of an increased CRC risk in patients with smoking and obesity, but do not highlight the increase in CRC risk in patients with DM.(More)
Fifty-eight patients with focal mass lesions involving the gastrointestinal tract were studied retrospectively. The diagnostic value of CT scans was seen by assessing the barium studies alone, then by combined review of radiographs and CT scans. Patient management decision making was similarly evaluated. CT scanning aided in diagnosis of the focal masses in(More)
In July 2012, more than 30 years after the initial HIV case reports, the United States (US) Food and Drug Administration (FDA) approved the first drug for the prevention of sexually acquired HIV infection. On the basis of compelling safety and efficacy data from pre-exposure pro-phylaxis (PrEP) trials of men who have sex with men (MSM) conducted across four(More)