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Nanomolar concentrations of temacrazine (1,4-bis[3-(6-oxo-6H-v-triazolo[4,5,1-de]acridin-5-yl)amino-propyl ]piperazine) were discovered to inhibit acute human immunodeficiency virus type 1 (HIV-1) infections and suppress the production of virus from chronically and latently infected cells containing integrated proviral DNA. This bistriazoloacridone(More)
A sensitive and quantitative cell-free infection assay, utilizing recombinant human T-cell leukemia virus type 1 (HTLV-1)-based vectors, was developed in order to analyze early events in the virus replication cycle. Previous difficulties with the low infectivity and restricted expression of the virus have prevented a clear understanding of these events.(More)
Neisseria gonorrhoeae is naturally competent for DNA transformation. In contrast to other natural prokaryotic DNA transformation systems, single-stranded donor DNA (ssDNA) has not previously been detected during transformation of N. gonorrhoeae. We have reassessed the physical nature of gonococcal transforming DNA by using a sensitive nondenaturing native(More)
The bacterial flagellum contains its own type III secretion apparatus that coordinates protein export with assembly at the distal end. While many interactions among export apparatus proteins have been reported, few have been examined with respect to the differential affinities and dynamic relationships that must govern the mechanism of export. FlhB, an(More)
appeared to be necessary to initiate the observed polarization of the cytoskeleton: HTLV-I infection of the cell and contact with another cell. It is not yet clear which molecules mediate these signals. HTLV-I Env protein is again a candidate for this function, because it is the only HTLV-I protein that is expressed intact on the outside of the infected(More)
evolved to promote and integrate virus production with VS formation. In addition to initiating signal transduc-tion in the infected cell, adhesion molecule engagement at the VS ostensibly activates the uninfected target cell. Activation would ensure expression of virus receptors by the uninfected cell and promote virus replication once the virus has entered(More)
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