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Two N-Terminal Domains of Kv4 K+ Channels Regulate Binding to and Modulation by KChIP1

• Robert H. Scannevin, Kewei Wang, +18 authors Kenneth J. Rhodes
• Neuron
• 2004

The family of calcium binding proteins called KChIPs associates with Kv4 family K(+) channels and modulates their biophysical properties. Here, using mutagenesis and X-ray crystallography, we explore… (More)

Improving the pharmacokinetic properties of biologics by fusion to an anti-HSA shark VNAR domain.

• Mischa Roland Müller, Kenneth A Saunders, +13 authors Caroline Jane Barelle
• mAbs
• 2012

Advances in recombinant antibody technology and protein engineering have provided the opportunity to reduce antibodies to their smallest binding domain components and have concomitantly driven the… (More)

Development of PF-06671008 , a Highly Potent Anti-P-cadherin / Anti-CD 3 Bispecific DART Molecule with Extended Half-Life for the Treatment of Cancer

• Adam R. Root, Wei Cao, +43 authors Laird Bloom
• 2016

Bispecific antibodies offer a promising approach for the treatment of cancer but can be challenging to engineer and manufacture. Here we report the development of PF-06671008, an extended-half-life… (More)

CDR-restricted engineering of native human scFvs creates highly stable and soluble bifunctional antibodies for subcutaneous delivery

• Brian Joseph Fennell, Barry McDonnell, +33 authors Orla Cunningham
• mAbs
• 2013

While myriad molecular formats for bispecific antibodies have been examined to date, the simplest structures are often based on the scFv. Issues with stability and manufacturability in scFv-based… (More)

GRB 060505 : A POSSIBLE SHORT-DURATION GAMMA-RAY BURST IN A STAR-FORMING REGION AT A REDSHIFT OF 0 . 09

• S. B. C ENKO, S. R. K ULKARNI, +18 authors Sofi Ersson
• 2007

On 2006May 5, a 4 s duration, low-energy, 10 erg, gamma-ray burst (GRB) was observed, spatially associated with a z 1⁄4 0:0894 galaxy. Here we report the discovery of the GRB optical afterglow and… (More)

Pharmacokinetic, biodistribution, and biophysical profiles of TNF nanobodies conjugated to linear or branched poly(ethylene glycol).

• Yulia Vugmeyster, Clifford A Entrican, +8 authors Xin Zhai Xu
• Bioconjugate chemistry
• 2012

Covalent attachment of poly(ethylene glycol) (PEG) to therapeutic proteins has been used to prolong in vivo exposure of therapeutic proteins. We have examined pharmacokinetic, biodistribution, and… (More)

Distinct in vitro binding properties of the anti-CD20 small modular immunopharmaceutical 2LM20-4 result in profound and sustained in vivo potency in cynomolgus monkeys

• Cheryl L. Nickerson-Nutter, Lioudmila Tchistiakova, +15 authors Kyri Dunussi-Joannopoulos
• Rheumatology
• 2011

OBJECTIVES To characterize the in vitro binding and effector function properties of CD20-directed small modular immunopharmaceutical (SMIP) 2LM20-4, and to compare its in vivo B-cell depletion… (More)

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