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Acting as a substrate at the serotonin (5-HT) transporter, (+)-MDMA (3,4-methylenedioxymethamphetamine), is a potent releaser of 5-HT and causes toxicity to 5-HT neurons after repeated exposure. (+)-MDMA also releases dopamine (DA), although with less potency. Since we have shown previously that the intrastriatal application of 5-HT facilities DA release,(More)
The beta-amyloid peptide-25-35 (beta A25-35) decreases the fluidity of mouse brain membranes in a concentration-depending fashion. First effects were already seen at a beta A25-35 concentration of 100 nmol/1. beta-Amyloid peptide(1-40) was similarly active. beta A25-35 also decreases the fluidity of human lymphocyte membranes and of membranes from the(More)
We derive general conditions for 100% frequency conversion in any doubly resonant nonlinear cavity, for both second-and third-harmonic generation via χ (2) and χ (3) nonlinearities. We find that conversion efficiency is optimized for a certain " critical " power depending on the cavity parameters, and assuming reasonable parameters we predict 100%(More)
We present experiments on second-harmonic generation from arrays of magnetic split-ring resonators and arrays of complementary split-ring resonators. In both cases, the fundamental resonance is excited by the incident femtosecond laser pulses under normal incidence, leading to comparably strong second-harmonic signals. These findings are discussed in terms(More)
Interacting many-body systems are characterized by stable configurations of objects--ranging from elementary particles to cosmological formations--that also act as building blocks for more complicated structures. It is often possible to incorporate interactions in theoretical treatments of crystalline solids by introducing suitable quasiparticles that have(More)
(-)-DS 121 [S-(-)-3-(3-cyanophenyl)-N-n-propyl piperidine], a dopamine autoreceptor preferring antagonist, has been shown to stimulate locomotor activity and induce conditioned place preference. However, the drug fails to facilitate intracranial self-stimulation or substitute for cocaine in cueing experiments, and it blocks cocaine self-administration. In(More)
We perform second-harmonic generation (SHG) microscopy with circularly polarized (CP) light to measure chirality of individual twisted-cross gold nanodimers. The chiral signatures, based on different SHG response for the two CP components of incident light, are clearly visible even with off-resonance excitation. The SHG responses of individual nanodimers(More)
We propose a platform to achieve ultra-high Quality factor (Q) optical resonators based on semiconductor nanowires. By defining one-dimensional photonic crystal at nanowire ends and engineering the micro-cavity pattern, cavities with Q of 3×10 5 and mode volume smaller than 0.2(λ/n) 3 have been designed. This represents an increase of almost three orders of(More)
We present the design and experimental comparison of femtogram L3-nanobeam photonic crystal cavities for optomechanical studies. Two symmetric nanobeams are created by placing three air slots in a silicon photonic crystal slab where three holes are removed. The nanobeams' mechanical frequencies are higher than 600 MHz with ultrasmall effective modal masses(More)