Stephan Renner

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We created nanometer-scale transmembrane channels in lipid bilayers by means of self-assembled DNA-based nanostructures. Scaffolded DNA origami was used to create a stem that penetrated and spanned a lipid membrane, as well as a barrel-shaped cap that adhered to the membrane, in part via 26 cholesterol moieties. In single-channel electrophysiological(More)
Attempts to construct artificial systems from biological molecules such as DNA and RNA by self-assembly are compatible with the recent development of synthetic biology. Genetic mechanisms can be used to produce or control artificial structures made from DNA and RNA, and these structures can in turn be used as artificial gene regulatory elements, in vitro as(More)
Computational approaches are frequently used in ligand design. We have developed two complementary techniques , the Protein Structure Similarity Clustering (PSSC) [1] and the Scaffold Tree [2,3]. The PSSC is based on subfold similarity around the binding sites of proteins. Its central hypothesis is that structurally similar binding sites bind structurally(More)
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