Stephan Morgenthaler

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SUMMARY The combination of evidence from independent studies has a curious history. The origins reach back at least to the beginning of the twentieth century. Since the mid-seventies the term meta-analysis (G. Glass, 1976 presidential address to the American Educational Research Association) has become popular in several fields, among them medical(More)
We study an adaptive statistical approach to analyze brain networks represented by brain connection matrices of interregional connectivity (connectomes). Our approach is at a middle level between a global analysis and single connections analysis by considering subnetworks of the global brain network. These subnetworks represent either the inter-connectivity(More)
Brain connectivity can be represented by a network that enables the comparison of the different patterns of structural and functional connectivity among individuals. In the literature, two levels of statistical analysis have been considered in comparing brain connectivity across groups and subjects: 1) the global comparison where a single measure that(More)
Detecting local differences between groups of connectomes is a great challenge in neuroimaging, because the large number of tests that have to be performed and the impact on multiplicity correction. Any available information should be exploited to increase the power of detecting true between-group effects. We present an adaptive strategy that exploits the(More)
Carcinogenesis is commonly described as a multistage process, in which stem cells are transformed into cancer cells via a series of mutations. In this article, we consider extensions of the multistage carcinogenesis model by mixture modeling. This approach allows us to describe population heterogeneity in a biologically meaningful way. We focus on finite(More)
Understanding brain structure and function can benefit from studying functional connectivity. A common methodology to measure functional connectivity between two brain regions is to estimate the correlation between their corresponding average time courses. Usually, these correlations are computed either via the Pearson estimator or the non-parametric(More)
Adult age-specific colorectal cancer incidence rates increase exponentially from maturity, reach a maximum, then decline in extreme old age. Armitage and Doll (1) postulated that the exponential increase resulted from "n" mutations occurring throughout adult life in normal "cells at risk" that initiated the growth of a preneoplastic colony in which(More)