Stephan Lorenz

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The atmospheric hydrological cycle is compared for diierent time slices of the late Quaternary. Simulations have been conducted with an atmospheric circulation model at T42 resolution, and we have performed a global evaluation of the atmospheric water vapor transport. The water export from the Atlantic catchment area, important for driving the large-scale(More)
BACKGROUND Computer-assisted surgery (CAS) can act as an intraoperative ruler in high tibial osteotomy (HTO) to visualize continuously the leg during surgery. QUESTIONS The aim of the study is to evaluate the accuracy of CAS with respect to preoperative planning and postoperative deviation from the planned leg axis in HTO. In addition, the influence of(More)
Migration and invasion of malignant cells are prerequisites for cancer progression and metastasis. The Bcl-2 family of proteins consists of about 25 members and has been extensively studied in the context of apoptosis. Despite the fact that small molecules targeting Bcl-2 proteins have already entered clinical trials, very few studies investigated a role of(More)
This study was done to determine whether there is a correlation between the notch volume and the notch width index (NWI) as measured on the three most frequently used radiographic views: the Holmblad 45 degrees, Holmblad 70 degrees, and Rosenberg view. The notch volume of 20 cadaveric knees was measured using Computed Tomography (CT). The Holmblad 45(More)
Despite the fact that new treatment regimes have improved overall survival of patients challenged by colorectal cancer (CRC), prognosis in the metastatic situation is still restricted. The Bcl-2 family of proteins has been identified as promising anti cancer drug target. Even though small molecules targeting Bcl-2 proteins are in clinical trials, little is(More)
We investigate the role of the tropics in the melting and reforming of the Laurentide ice sheet on glacial timescales using an atmospheric general circulation model. It is found that warming of tropical sea surface temperatures (SST) from glacial boundary conditions, as observed at the end of glacial periods [Bard et al., causes a large increase in summer(More)
Colorectal cancer is the third most common malignancy in humans and novel therapeutic approaches are urgently needed. Autophagy is an evolutionarily highly conserved cellular process by which cells collect unnecessary organelles or misfolded proteins and subsequently degrade them in vesicular structures in order to refuel cells with energy. Dysregulation of(More)
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