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BACKGROUND The interrogation of proteomes ("proteomics") in a highly multiplexed and efficient manner remains a coveted and challenging goal in biology and medicine. METHODOLOGY/PRINCIPAL FINDINGS We present a new aptamer-based proteomic technology for biomarker discovery capable of simultaneously measuring thousands of proteins from small sample volumes(More)
Recently, we reported a SOMAmer-based, highly multiplexed assay for the purpose of biomarker identification. To enable seamless transition from highly multiplexed biomarker discovery assays to a format suitable and convenient for diagnostic and life-science applications, we developed a streamlined, plate-based version of the assay. The plate-based version(More)
The fast growth of information technology has been sustained by continuous scaling down of the silicon-based metal-oxide field-effect transistor. However, such technology faces two major challenges to further scaling. First, the device electrostatics (the ability of the transistor's gate electrode to control its channel potential) are degraded when the(More)
That a nanoparticle (NP) (for example of gold) residing above a gold mirror is almost as effective a surface enhanced Raman scattering (SERS) substrate (when illuminated with light of the correct polarization and wavelength) as two closely coupled gold nanoparticles has been known for some time. The NP-overmirror (NPOM) configuration has the valuable(More)
Bilayer graphene has attracted wide attention due to its unique band structure and bandgap tunability under specific (Bernal or AB) stacking order. However, it remains challenging to tailor the stacking order and to simultaneously produce large-scale and high-quality bilayer graphene. This work introduces a fast and reliable method of growing high-quality(More)
The effects of V/III ratio and seed window orientation on the coalescence of epitaxial lateral overgrowth InP over SiO 2 using metal organic vapor-phase epitaxy with tertiary butyl phosphine were investigated. Parallel lines having h = 60° and 30° off [0 " 11] were coalesced, and their lateral growth rate variation with V/III was measured. Coalescence of(More)
In view of code verification of finite element implementations and for material parameter identification purposes it is of interest to make use of stress algorithms developed for three-dimensional finite element computations. In the case of homogeneous deformations various boundary-conditions for given displacements or stresses are possible and define a(More)
[This is a penultimate version. Please quote only from the published version. Abstract: The proper evaluation of a theory's virtues seems to require taking into account what the theory is indirectly or implicitly committed to, in addition to what it explicitly says. Most extant proposals for criteria of theory choice in the literature spell out the relevant(More)
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