Stephan J. Sigrist

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Bruchpilot, a Protein with Homology to ELKS/CAST, Is Required for Structural Integrity and Function of Synaptic Active Zones in Drosophila

Dhananjay A. Wagh, Tobias M. Rasse, +11 authors Erich Buchner
Neuron
2006

Neurotransmitters are released at presynaptic active zones (AZs). In the fly Drosophila, monoclonal antibody (MAB) nc82 specifically labels AZs. We employ nc82 to identify Bruchpilot protein (BRP) as… (More)

Bruchpilot promotes active zone assembly, Ca2+ channel clustering, and vesicle release.

Robert J Kittel, Carolin Wichmann, +11 authors Stephan J. Sigrist
Science
2006

The molecular organization of presynaptic active zones during calcium influx-triggered neurotransmitter release is the focus of intense investigation. The Drosophila coiled-coil domain protein… (More)

Oxygen Stress: A Regulator of Apoptosis in Yeast

Frank Madeo, Eleonore Fröhlich, +4 authors K. Fröhlich
The Journal of cell biology
1999

Oxygen radicals are important components of metazoan apoptosis. We have found that apoptosis can be induced in the yeast Saccharomyces cerevisiae by depletion of glutathione or by low external doses… (More)

Frank Madeo, Eva Herker, +8 authors Kai Uwe Fröhlich
Molecular cell
2002

Yeast can undergo cell death accompanied by cellular markers of apoptosis. However, orthologs of classical mammalian apoptosis regulators appeared to be missing from the yeast genome, challenging a… (More)

Maturation of active zone assembly by Drosophila Bruchpilot

Wernher Fouquet, David Owald, +7 authors Stephan J. Sigrist
The Journal of cell biology
2009

Synaptic vesicles fuse at active zone (AZ) membranes where Ca(2+) channels are clustered and that are typically decorated by electron-dense projections. Recently, mutants of the Drosophila… (More)

Chronological aging leads to apoptosis in yeast

Eva Herker, Helmut Jungwirth, +7 authors Frank Madeo
The Journal of cell biology
2004

During the past years, yeast has been successfully established as a model to study mechanisms of apoptotic regulation. However, the beneficial effects of such a cell suicide program for a unicellular… (More)

Drosophila fizzy-related Down-Regulates Mitotic Cyclins and Is Required for Cell Proliferation Arrest and Entry into Endocycles

We demonstrate that fizzy-related (fzr), a conserved eukaryotic gene, negatively regulates the levels of cyclins A, B, and B3. These mitotic cyclins that bind and activate cdk1(cdc2) are rapidly… (More)

Rapid Activity-Dependent Modifications in Synaptic Structure and Function Require Bidirectional Wnt Signaling

Bulent Ataman, James W. Ashley, +4 authors Vivian Budnik
Neuron
2008

Activity-dependent modifications in synapse structure play a key role in synaptic development and plasticity, but the signaling mechanisms involved are poorly understood. We demonstrate that… (More)

An AIF orthologue regulates apoptosis in yeast

Silke Wissing, Paula Ludovico, +13 authors Frank Madeo
The Journal of cell biology
2004

Apoptosis-inducing factor (AIF), a key regulator of cell death, is essential for normal mammalian development and participates in pathological apoptosis. The proapoptotic nature of AIF and its mode… (More)

Glutamate receptor dynamics organizing synapse formation in vivo

Tobias M. Rasse, Wernher Fouquet, +11 authors Stephan J. Sigrist
Nature Neuroscience
2005

Insight into how glutamatergic synapses form in vivo is important for understanding developmental and experience-triggered changes of excitatory circuits. Here, we imaged postsynaptic densities… (More)

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