Stephan J. Zuend

Learn More
Supplementary Methods General Experimental Procedures. Reactions were carried out in oven-dried round-bottomed flasks, unless otherwise noted. The flasks were fitted with rubber septa and reactions were conducted under a positive pressure of nitrogen. Stainless steel syringes or cannulae were used to transfer air-and moisture-sensitive liquids. Flash(More)
Cationic organic intermediates participate in a wide variety of useful synthetic transformations, but their high reactivity can render selectivity in competing pathways difficult to control. Here, we describe a strategy for inducing enantioselectivity in reactions of protio-iminium ions, wherein a chiral catalyst interacts with the highly reactive(More)
Alpha-amino acids are the building blocks of proteins and are widely used as components of medicinally active molecules and chiral catalysts. Efficient chemo-enzymatic methods for the synthesis of enantioenriched alpha-amino acids have been developed, but it is still a challenge to obtain non-natural amino acids. Alkene hydrogenation is broadly useful for(More)
We describe efforts to understand the structure and reactivity of lithiated cyclohexanone N-cyclohexylimine. The lithioimine affords complex solvent-dependent distributions of monomers, dimers, and trimers in a number of ethereal solvents. Careful selection of solvent provides exclusively monosolvated dimers. Rate studies on the C-alkylations reveal chronic(More)
  • 1