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The pathogen causing Dutch elm disease makes host trees attract insect vectors
Dutch elm disease is caused by the fungal pathogen Ophiostoma novo-ulmi which is transmitted by the native elm bark beetle, Hylurgopinus rufipes. We have found that four semiochemicals (theExpand
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Comparative metabolomics reveals biogenesis of ascarosides, a modular library of small-molecule signals in C. elegans.
In the model organism Caenorhabditis elegans, a family of endogenous small molecules, the ascarosides function as key regulators of developmental timing and behavior that act upstream of conservedExpand
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Targeted metabolomics reveals a male pheromone and sex-specific ascaroside biosynthesis in Caenorhabditis elegans.
In the model organism Caenorhabditis elegans, a class of small molecule signals called ascarosides regulate development, mating, and social behaviors. Ascaroside production has been studied in theExpand
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Succinylated Octopamine Ascarosides and a New Pathway of Biogenic Amine Metabolism in Caenorhabditis elegans*
Background: Ascarosides play central roles regulating C. elegans behavior and development. Results: L1 larvae produce starvation-dependent ascarosides based on succinylated octopamine. Conclusion:Expand
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Erratum: Mating dynamics in a nematode with three sexes and its evolutionary implications
Organisms have evolved several modes of reproduction, varying from species with separate sexes to species that replicate exclusively from a single parent1,2. Between these extremes lie mixed breedingExpand
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A Modular Library of Small Molecule Signals Regulates Social Behaviors in Caenorhabditis elegans
Comparative metabolomics reveals a modular library of small molecule signals that function as aggregation pheromones in the nematode C. elegans.
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Evolution of ‘pollinator’- attracting signals in fungi
Fungi produce a plethora of secondary metabolites yet their biological significance is often little understood. Some compounds show well-known antibiotic properties, others may serve as volatileExpand
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Conserved nematode signalling molecules elicit plant defenses and pathogen resistance
Plant-defense responses are triggered by perception of conserved microbe-associated molecular patterns (MAMPs), for example, flagellin or peptidoglycan. However, it remained unknown whether plantsExpand
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Mating dynamics in a nematode with three sexes and its evolutionary implications
Nematodes have diverse reproductive strategies, which make them ideal subjects for comparative studies to address how mating systems evolve. Here we present the sex ratios and mating dynamics of theExpand
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Complex small-molecule architectures regulate phenotypic plasticity in a nematode.
Chemistry the worm's way: The nematode Pristionchus pacificus constructs elaborate small molecules from modified building blocks of primary metabolism, including an unusual xylopyranose-basedExpand
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