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Gamma aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the human brain. It plays a decisive role in a variety of nervous system disorders, such as anxiety disorders, epilepsy, schizophrenia, insomnia, and many others. The reproducibility of GABA quantification results obtained with a single-voxel spectroscopy J-difference editing(More)
OBJECTIVE To develop and assess a combined reading for contrast-enhanced magnetic resonance (CE-MRI) and diffusion weighted imaging (DWI) adapted to the BI-RADS for multiparametric MRI of the breast at 3 T. METHODS A total of 247 patients with histopathologically verified breast lesions were included in this IRB-approved prospective study. All patients(More)
PURPOSE To qualitatively and quantitatively compare the diagnostic value of diffusion-weighted (DW) magnetic resonance (MR) imaging based on standard single-shot echo-planar imaging and readout-segmented echo-planar imaging in patients with breast cancer at 3.0 T. MATERIALS AND METHODS Institutional review board approval and written informed consent were(More)
Neurologic disease in glutaryl-CoA dehydrogenase (GCDH) deficiency usually presents with acute encephalopathic crises before 2 years of age. The authors report two previously asymptomatic patients with macrocephaly presenting with progressive neurologic deterioration and a severe leukoencephalopathy during adolescence or adulthood.
PURPOSE To evaluate proton magnetic resonance (MR) spectroscopic imaging with high spatial resolution for preoperative grading of suspected World Health Organization grades II and III gliomas. MATERIALS AND METHODS Institutional ethics committee approval and informed consent were obtained for control subjects but were not required for the retrospective(More)
Currently, there is a lack of stand-alone geo-monitoring systems for harsh environments that are easy to configure, deploy and manage, while at the same time adhering to science grade quality requirements. In a joint computer and geoscience project we have built and deployed a wireless sensor network for measuring permafrost related parameters. Using these(More)
PURPOSE To develop a 3.0 Tesla breast imaging protocol that combines high temporal and spatial resolution three-dimensional MR sequences for quantitative time course and morphologic analysis of breast lesions. MATERIALS AND METHODS Thirty-four patients were included in the study (age range, 31-82; mean age, 54.3). The study protocol was approved by the(More)
OBJECTIVES Sixty three healthy subjects were measured to assess dependence of brain metabolites on age using short- and long echo time spectroscopy in different brain regions. MATERIAL AND METHODS Younger and elderly humans were measured with long echo time (TE=135ms) 3D-MR-spectroscopic imaging (MRSI) (10 subjects) and with ultra-short echo (TE=11ms)(More)
BACKGROUND AND PURPOSE The new 3.0-T imagers theoretically yield double the signal-to-noise ratio (SNR) and spectral resolution of 1.5-T instruments. To assess the possible improvements for multivoxel 3D proton MR spectroscopy (1H-MRS) in the human brain, we compared the SNR and spectral resolution performance with both field strengths. METHODS(More)
The PermaSense project has set the ambitious goal of gathering real-time environmental data for high-mountain permafrost in unattended operation over multiple years. This paper discusses the specialized sensing and data recovery architecture tailored to meet the precision, reliability and durability requirements of scientists utilizing the data for model(More)