Stephan Gehring

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Interleukin-27 (IL-27) has been described to be highly expressed during the very first days after birth, but secretion of IL-27 by dendritic cells during the course of childhood has not been described. In our present study we enrolled children (n = 55) in the range from 1 day of to 18 years of age and asked for a small whole blood sample. The capacity of(More)
OBJECTIVE Therapeutic options for the tuberous sclerosis complex (TSC) syndrome showed varying outcomes. Malfunctional tsc1/tsc2 genes leave mTOR uninhibited, a positive downstream modulator of the innate proinflammatory immune system, which has not yet been described in pediatric patients with TSC. METHODS Using polymerase chain reaction (PCR) gene(More)
Aims In recent years, the role of gut flora in inflammatory bowel diseases (IBD), including ulcerative colitis (UC) and Crohn´s Disease (CD) has become focus of intense research. The working hypothesis is that an altered microbiota causes mucosal inflammation in a genetically susceptible individual. Understanding the microbiota´s role in the pathogenesis of(More)
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