Stepan Tymoshenko

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Toxoplasma gondii is a human pathogen prevalent worldwide that poses a challenging and unmet need for novel treatment of toxoplasmosis. Using a semi-automated reconstruction algorithm, we reconstructed a genome-scale metabolic model, ToxoNet1. The reconstruction process and flux-balance analysis of the model offer a systematic overview of the metabolic(More)
Plasmodium falciparum is an obligate intracellular parasite and the leading cause of severe malaria responsible for tremendous morbidity and mortality particularly in sub-Saharan Africa. Successful completion of the P. falciparum genome sequencing project in 2002 provided a comprehensive foundation for functional genomic studies on this pathogen in the(More)
Novel antimalarial therapies are urgently needed for the fight against drug-resistant parasites. The metabolism of malaria parasites in infected cells is an attractive source of drug targets but is rather complex. Computational methods can handle this complexity and allow integrative analyses of cell metabolism. In this study, we present a genome-scale(More)
The biosynthesis of lycopene by the strain Streptomyces globisporus 4Lcp has been studied at synthetic media with different sources of carbon and nitrogen. It has been shown that the highest yield of lycopene (2.0-3.0 microg/l), in case of cultivation in shacked flasks, has been observed when glycerol is used as a source of carbon and sodium or potassium(More)
The screening of the positive regulators of landomycin E biosynthesis has been conducted among exogenous metabolites of the museum and freshly isolated Streptomycetes strains by means of cosynthesis test using mutant strain Streptomyces globisporus 1912-82. The ability to produce the exogenous metabolites restoring landomycin E biosynthesis by B2 strain was(More)
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