Stella Stefanova

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OBJECTIVE Bruton's tyrosine kinase (BTK) plays a critical role in B cell development and function. We recently described a selective BTK inhibitor, RN486, that blocks B cell receptor (BCR) and Fcγ receptor signaling and is efficacious in animal models of arthritis. The aim of this study was to examine the potential efficacy of BTK in systemic lupus(More)
It is shown, that bacteria of the strain Gluconobacter suboxydans entrapped in a polyacrylamide gel are capable to convert D-sorbitol to L-sorbose with a sufficiently high reaction rate. The kinetics of the studied process remains the same as it has been found for the case of free cells. Both semicontinuous and continuous patterns are accomplished.
PURPOSE To evaluate the role of some nuclear medicine approaches such as (99m)Tc-MIBI scan and (131)I whole-body scintigraphy (WBS) in the monitoring of patients with differentiated thyroid cancer (DTC). PATIENTS AND METHODS 95 patients (69F/26M) aged 17-74 years (mean 44.2) with DTC (56 cases with papillary, 20 with follicular and 19 with(More)
Based on 2004 CEAP-ARMS Phase II data, higher-sales farms not participating in a conservation programme adopted farmland conservation structures much more intensively on wheat fields than did any other farm-size type among conservation programme participants or non-participants. Survey results suggest that wheat farms not participating in a conservation(More)
We studied the effect of the benzodiazepine derivative alprazolam on [3H]-flunitrazepam binding with a brain synaptosomal fraction of experimental animals in vitro and in vivo. The in vivo experiments were carried out in intact cats and mice with social isolation. Alprazolam did not change the density of benzodiazepine receptors in intact animals, but(More)
The effects of pressure on the crushing strength of UAS pellets, produced by a laboratory pressing machine were investigated. Physico-chemical properties of UAS pellets were studied by Electron Microscope (EMS), X-ray, Infra-Red Derivatography with a view to identifying the reasons for improvement in physico-mechanical properties. It was proved that there(More)