Learn More
OBJECTIVES This study investigated whether inhibiting late Na(+) current by using ranolazine improved diastolic function in patients with heart failure with preserved ejection fraction (HFpEF). BACKGROUND HFpEF accounts for >50% of all HF patients, but no specific treatment exists. METHODS The RALI-DHF (RAnoLazIne for the Treatment of Diastolic Heart(More)
BACKGROUND Studies of cancer risk and molecular carcinogenesis suggest a role for inflammation in cancer development and progression. The authors sought to determine whether specific blood proteins associated with inflammation predict for outcomes in men with metastatic androgen-independent prostate cancer (AIPC) who are initiating docetaxel-based(More)
BACKGROUND The nonmedical abuse of prescription opioids via intranasal administration is a growing problem. The objective of this study is to investigate of the typical presentation of intranasal opioid-acetaminophen abuse and outline optimal therapy. METHODS This study was a retrospective chart review. Patients with intranasal pathology from inhalation(More)
Heterotopic ossification is a common complication of Orthopaedic Trauma Association (OTA) type C distal humerus fractures and ulnohumeral fracture dislocations. The purpose of this study was to precisely define the incidence of heterotopic ossification following major elbow trauma and to identify risk factors for the development of clinically significant(More)
OBJECTIVES/HYPOTHESIS Cone beam computed tomography (CBCT) has emerged as a low radiation dose alternative to traditional computed tomography (CT) to evaluate the paranasal sinuses. The purpose of our study was to determine how often clinically important findings would be missed if CBCT was used routinely for sinus imaging. STUDY DESIGN Retrospective(More)
Chronic rhinosinusitis (CRS) is a prevalent health condition characterized by sinonasal mucosal inflammation lasting at least 12 weeks. Heterogeneous in clinical presentation, histopathology, and therapeutic response, CRS represents a spectrum of disease entities with variable pathophysiology. Increased knowledge of cellular and molecular derangements in(More)
Mycoplasma pneumoniae-positive clinical specimens obtained from the United States and China during the same period were studied for their molecular characteristics. We found much more diverse genotypes and a lower prevalence of macrolide resistance in the U.S. specimens. Data from the study also showed an association of the resistance with certain genotypes.
This paper introduces a new experience-driven design concept to public spaces, such as bus stops, to strengthen connections between cities and their citizens. With the prototype described here we are provoking inquiry into whether the "technology" that is a bus stop, with high tech augmentations can engender civic engagement and more interconnected cities.(More)
M are the preferred treatment for infections caused by Mycoplasma pneumoniae in children (1). Since 2000, macrolide resistance has developed in Asia and has now been reported from many parts of the world (2). This resistance is of a high level and has been associated with longer duration of fever, cough, and hospital stay and the need to switch to(More)