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Health hazards resulting form the exposure to high-Z and high energy particles such as carcinogenesis, damage to the central nervous system or cataractogenesis are of major concern in planning manned missions to Moon and Mars. Among these effects carcinogenesis is currently considered to be the main risk factor for astronauts. One important biomarker of(More)
Since 2006 a clinical phase I/II study is carried out treating prostate cancer patients with a combination of C-ion irradiation and IMRT (C-ion treatment at GSI, IMRT in Heidelberg). In parallel to this therapy, a study investigating chromosome aberrations in blood lymphocytes of prostate cancer patients is performed, as described in [1]. Chromosome(More)
The long-term "fate" of normal human cells after single hits of charged particles is one of the oldest unsolved issues in radiation protection and cellular radiobiology. Using a high-precision heavy-ion microbeam we could target normal human fibroblasts with exactly one or five carbon ions and measured the early cytogenetic damage and the late behaviour(More)
Ionizing radiation has been reported to promote a state of apparent cell-cycle arrest in both normal and tumour cell lines closely resembling the senescent phenotype [1,2]. The arrest is sometimes reversed and the cell either resumes proliferation or, alternatively, differentiates. Although DNA damage is thought to be the main effector of the senescent-like(More)
Introduction: According to the " free-radical theory of ageing " during ageing elevated levels of free radicals and reactive oxygen species (ROS) induce damages of lipids, proteins and nucleic acids in cells (1). Enhanced oxidative damage shortens lifespan (2). In mitochondria ~90% of the total cellular ROS is produced mostly by respiration. Respiratory(More)
Xenogenic transplantation models have been developed to study human hematopoiesis in immunocompromised murine recipients. They still have limitations and therefore it is important to delineate all players within the bone marrow that could account for species-specific differences. Here, we evaluated the proliferative capacity, morphological and physical(More)
In multicellular organisms stem cells are involved in tissue regeneration, which is regulated by apoptosis (programmed cell death). An early event of apoptosis is the externalisation of membrane phospholipids to the ex-tracellular environment, on which Annexin-V is able to bind with a high affinity. The later stages of apoptosis are characterized by the(More)
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