Steffen Kandler

Learn More
Neuronal cultures are small living networks in a closed system. This paper investigates the question whether it is possible to discover the functional connectivity and to model the dynamics of such neuronal cultures. Doing so may contribute to a better understanding of neural information processing. We employ a machine learning approach, which constructs(More)
Cultured neuronal networks are an interesting experimental model in which neurons are freed from cortical architecture and plated on microelectrode arrays (MEA). Present in their dynamics are periods of strongly synchronized spiking by the network, termed 'bursting', whose role is not understood but dominates network dynamics and, due to its resistance to(More)
The emergence of spontaneous bursting events in developing neuronal networks likely depends on the evolving network connectivity. Theoretical models have shown that hierarchical network structures embedding clusters of strongly interconnected neurons are optimal for initiating and sustaining spontaneous activity [1]. It is conceivable that(More)
The principle of self-organization is fundamental for the adaptive formation and modification of functional circuits in many parts of the nervous system. At a cellular level, cortical micro-circuitry evolves on the basis of activity-dependent biochemical processes that guide neuronal wiring and that are differentially regulated in the course of development.(More)
  • 1