Steffen Heublein

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BACKGROUND Sepsis, the most severe manifestation of acute infection, poses a major challenge to health care systems around the world. To date, adequate data on the incidence and mortality of sepsis in Germany have been lacking. METHODS Nationwide case-related hospital DRG statistics for the years 2007-2013 were used to determine the in-hospital incidence(More)
Modern approaches for flexible workflow modeling and execution foster the convenient combination of graph- and rule-based business logic. Specifically, the pattern-based adaptation of reference workflows to changing data contexts allows for a better modeling of variance and its evolution over time than traditional approaches. We recently presented variant(More)
OBJECTIVES This article systematically reviews research on the costs of sepsis and, as a secondary aim, evaluates the quality of economic evaluations reported in peer-reviewed journals. METHODS We systematically searched the MEDLINE, National Health Service (Abstracts of Reviews of Effects, Economic Evaluation and Health Technology Assessment),(More)
Acquired severe aplastic anaemia (AA) is a serious condition caused by immune-triggered bone marrow failure. For patients not eligible for bone marrow transplantation, treatment of choice is immunosuppression by a combined treatment with antithymocyte globulin (ATG) and cyclosporine. The debate on treatment optimization in AA is focused on conflicting data(More)
BACKGROUND Health care-associated infections (HAIs) can be associated with increased health care costs. We examined extra length of hospital stay (LOS) and associated per diem costs attributable to HAIs in a large academic medical center. METHODS Data for analysis were acquired in a preinterventional phase of a prospective cohort study (ALERTS) conducted(More)
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