Steffen Heublein

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Acquired severe aplastic anaemia (AA) is a serious condition caused by immune-triggered bone marrow failure. For patients not eligible for bone marrow transplantation, treatment of choice is immunosuppression by a combined treatment with antithymocyte globulin (ATG) and cyclosporine. The debate on treatment optimization in AA is focused on conflicting data(More)
BACKGROUND Sepsis, the most severe manifestation of acute infection, poses a major challenge to health care systems around the world. To date, adequate data on the incidence and mortality of sepsis in Germany have been lacking. METHODS Nationwide case-related hospital DRG statistics for the years 2007-2013 were used to determine the in-hospital incidence(More)
Modern approaches for flexible workflow modeling and execution foster the convenient combination of graph- and rule-based business logic. Specifically, the pattern-based adaptation of reference workflows to changing data contexts allows for a better modeling of variance and its evolution over time than traditional approaches. We recently presented variant(More)
OBJECTIVES This article systematically reviews research on the costs of sepsis and, as a secondary aim, evaluates the quality of economic evaluations reported in peer-reviewed journals. METHODS We systematically searched the MEDLINE, National Health Service (Abstracts of Reviews of Effects, Economic Evaluation and Health Technology Assessment),(More)
BACKGROUND Health care-associated infections (HAIs) can be associated with increased health care costs. We examined extra length of hospital stay (LOS) and associated per diem costs attributable to HAIs in a large academic medical center. METHODS Data for analysis were acquired in a preinterventional phase of a prospective cohort study (ALERTS) conducted(More)
Methods We performed a nation-wide analysis of coded sepsis cases from 2007 to 2013 based on German Diagnosis Related Groups Statistics, Hospital Statistics, and Causes of Death Statistics. Sepsis cases were identified by a) clinical sepsis codes for sepsis, severe sepsis and septic shock (R65.0!, R65.1!, R57.2, respectively, as secondary diagnosis) from(More)
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