Steffen Hüttner

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Streptomyces arenae is able to grow on acetate or ethanol as the sole carbon source. The metabolic pathway used for gluconeogenesis from C2 compounds in streptomycetes has not yet been characterized. In the course of a sequencing project we identified the gene for malate synthase (aceB), a key enzyme in the glyoxylate cycle in S. arenae. The gene was cloned(More)
One mechanism proposed to play a role in T-cell depletion in human immunodeficiency virus (HIV) infection is apoptosis (activation-induced cell death). We assessed whether apoptosis is related to activation of T cells in vivo and its possible triggers. DNA was extracted from peripheral blood mononuclear cells (PBMC) taken from 16 vertically HIV-infected(More)
New deep-sequencing technologies are applied to transcript sequencing (RNA-seq) for transcriptomic studies. However, currenta pproaches are based on the availabilityo far eference ge-nome sequence for read mapping. We present Passage,amethod for efficientr ead clustering in the absence of ar eference genome that allows sequencing-based comparativet(More)
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