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Recruiting polymorphonuclear neutrophil granulocytes (PMNs) from circulation and bone marrow to the site of inflammation is one of the pivotal mechanisms of the innate immune system. During inflammation, the enzyme heme oxygenase 1 (HO-1) has been shown to reduce PMN migration. Although these effects have been described in various models, underlying(More)
Successful concepts of self-organization found in natural systems can enable enterprise information systems to address their complexity issues. In this paper, we propose an analysis of self-organization approaches found in natural sciences and information technology. Based on common classes both for application areas and mechanisms, these two fields are(More)
At first glance, it seems to be quite surprising that so far traditional business process-oriented knowledge management techniques have not been transferred to research in order to improve the efficiency of scientific work on a larger scale. But due to the high variability and unpredictability of scientific work processes, these techniques are not(More)
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