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  • P. Bettica, Gianluca Nucci, +5 authors Robert Alexander
  • Medicine
  • Journal of psychopharmacology
  • 2012 (First Publication: 1 August 2012)
  • The orexin system plays a major role in the integration of metabolic and circadian influences that drive wakefulness. This paper describes initial Phase I trials of a novel dual orexin receptorContinue Reading
  • Emiliangelo Ratti, Kevin M. Bellew, +8 authors Sofia Wiedling Fernandes
  • Psychology, Medicine
  • Journal of clinical psychopharmacology
  • 2011 (First Publication: 1 December 2011)
  • Clinical study results for neurokinin (NK) receptor antagonists in the treatment of depression have been mixed, with Phase III studies failing to fulfill the early promise demonstrated in Phase IIContinue Reading
  • Ernest H Choy, Marina Bendit, +6 authors John Toso
  • Medicine
  • Arthritis Research & Therapy
  • 2013
  • IntroductionOncostatin M (OSM) has been implicated in the pathophysiology of rheumatoid arthritis (RA) through its effect on inflammation and joint damage. GSK315234 is a humanised anti-OSMContinue Reading
  • Susan M. Learned, Ole Graff, +9 authors Emiliangelo Ratti
  • Psychology, Medicine
  • Journal of psychopharmacology
  • 2012 (First Publication: 1 May 2012)
  • GSK372475 is a triple reuptake inhibitor with approximately equipotent inhibition of serotonin, norepinephrine, and dopamine transporters. Two randomized, placebo- and active-controlled, double-blindContinue Reading
  • Stefano Zamuner, Brendan M. Johnson, +5 authors S. A. A. Fernandes
  • Medicine
  • British journal of clinical pharmacology
  • 2010 (First Publication: 1 October 2010)
  • AIM To evaluate the impact of single and repeated doses casopitant on the pharmacokinetics of single dose midazolam and nifedipine (CYP3A substrates) in healthy subjects. The effect on debrisoquineContinue Reading
  • Amir Inamdar, Emilio V Merlo-Pich, +8 authors Emiliangelo Ratti
  • Psychology, Medicine
  • Journal of psychopharmacology
  • 2014 (First Publication: 1 June 2014)
  • Pro-inflammatory cytokines (PICs) may play important pathophysiological roles in some forms of Major Depressive Disorder (MDD). The p38 MAPK inhibitor losmapimod (GW856553) attenuates theContinue Reading