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A method for finding the center of cryo-EM images which correspond to the projections of a symmetric 3D structure, based on mathematical properties of symmetry adapted functions and the Fourier-Bessel transform, is presented. It is a model independent one-step procedure with no parameters to be chosen by the user. The proposed method is tested in one… (More)
Let S be a generic submanifold of C N of real codimension m. In this work we continue the study, carried over by various authors, of the set of analytic discs attached to S. Moreover we look at the subspaces of C N obtained by evaluating at 0 and at 1, holomorphic maps which are the infinitesimal deformations of analytic discs attached to S.
An account is given of the latest developments of the AMoRe package: new rotational search algorithms, exploitation of noncrystallographic symmetry, generation and use of ensemble models and interactive graphical molecular replacement.
Many animal and plant viruses rely on vectors for their transmission from host to host. Grapevine fanleaf virus (GFLV), a picorna-like virus from plants, is transmitted specifically by the ectoparasitic nematode Xiphinema index. The icosahedral capsid of GFLV, which consists of 60 identical coat protein subunits (CP), carries the determinants of this… (More)
I'm your Venus: the crystal structure of the human methylamine-induced form of α(2)-macroglobulin (α(2)M) shows its large central cavity can accommodate two medium-sized proteinases. Twelve major entrances provide access for small substrates to the cavity and the still-active trapped "prey". The structure unveils the molecular basis of the unique "venus… (More)
The FFT calculation of spherical harmonics, Wigner D matrices and rotation function has been extended to all angular variables in the AMoRe molecular replacement software. The resulting code avoids singularity issues arising from recursive formulas, performs faster and produces results with at least the same accuracy as the original code. The new code aims… (More)
The combination of transmission electron microscopy with X-ray diffraction data is usually limited to relatively large particles. Here, the approach is continued one step further by utilizing negative staining, a technique that is of wider applicability than cryo-electron microscopy, to produce models of medium-size proteins suitable for molecular… (More)
We show that for every smooth generic projective hyper-surface X ⊂ P n+1 , there exists a proper subvariety Y X such that codimX Y ≥ 2 and for every non constant holomorphic entire map f : C → X one has f (C) ⊂ Y , provided deg X ≥ 2 n 5. In particular , we obtain an effective confirmation of the Kobayashi conjecture for threefolds in P 4 .