Stefano Partelli

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BACKGROUND The value of surgical resection in the management of pancreatic neuroendocrine tumors (PNET) with liver metastases (LM) is still debated. The aim of this study was to evaluate the outcomes of surgery of PNET with LM. METHODS Patients with PNET with synchronous LM between 2000 and 2011 from 4 high-volume institutions were included. The patients(More)
Pancreatic neuroendocrine tumors (PanNETs) are rare neoplasms with a more favorable prognosis than pancreatic adenocarcinoma. However, up to 60% of patients with PanNETs present with advanced disease or will recur after surgical resection, requiring multimodal therapy to improve clinical outcomes [1]. In 2011, two phase 3, randomized, placebo-controlled(More)
BACKGROUND AND OBJECTIVES In recent years there has been an increase in the diagnosis of cystic tumors of the pancreas. In this setting, difficult diagnostic problems and different therapeutic management can be proposed. MATERIAL AND METHODS A review of the literature and authors experience were undertaken. RESULTS Cystic tumors of the pancreas include(More)
BACKGROUND Despite dedicated emergency theatre, emergency surgery can be often delayed due to competing urgencies, suggesting a need for innovative theatre time management. AIM To investigate if a change in the emergency theatre prioritisation affects outcomes for a common urgent operation such as appendicectomy. METHODS We prospectively recorded data(More)
BACKGROUND Cystic pancreatic endocrine tumors (CPETs) are rare lesions and their biological features have been scarcely investigated. AIM To compare clinical and pathological features of resected non-functioning sporadic CPETs (NF-CPETs) with solid pancreatic endocrine tumors (SPETs) in a single-institution experience. METHODS All patients with a(More)
BACKGROUND The aim of this study was to evaluate the efficacy of conservative treatment for nonfunctioning pancreatic neuroendocrine neoplasms (NF-PNEN) ≤2 cm in multiple endocrine neoplasia type 1 (MEN1)-affected patients compared with surgical treatment. METHODS The databases of 4 tertiary referral institutions (San Raffaele Scientific Institute, Milan;(More)
Appropriate surgical strategies for management of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas are a matter of debate. Preoperative and intraoperative evaluation of malignant potential of IPMN and of patient's comorbidities is of paramount importance to balance potential complications of surgery with tumors' risk of being or becoming(More)
The diagnosis of pancreatic neuroendocrine tumours (PanNETs) is increasing owing to more sensitive detection methods, and this increase is creating challenges for clinical management. We performed whole-genome sequencing of 102 primary PanNETs and defined the genomic events that characterize their pathogenesis. Here we describe the mutational signatures(More)
Neuroendocrine carcinomas (NEC) of the pancreas are defined by a mitotic count > 20 mitoses/10 high power fields and/or Ki67 index > 20%, and included all the tumors previously classified as poorly differentiated endocrine carcinomas. These latter are aggressive malignancies with a high propensity for distant metastases and poor prognosis, and they can be(More)