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Exosomes increase the therapeutic index of doxorubicin in breast and ovarian cancer mouse models.
AIM To demonstrate that exosomes (exo) could increase the therapeutic index of doxorubicin (DOX). MATERIALS & METHODS Exosomes were characterized by nanoparticle tracking analysis and western blot.Expand
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Inorganic Nanoparticles for Cancer Therapy: A Transition from Lab to Clinic.
BACKGROUND Inorganic nanoparticles (NPs) including those derived from metals (e.g., gold, silver), semiconductors (e.g., quantum dots), carbon dots, carbon nanotubes, or oxides (e.g., iron oxide),Expand
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Exosomal doxorubicin reduces the cardiac toxicity of doxorubicin.
AIM To test the efficacy and toxicity of exosomal doxorubicin (exoDOX) compared with free doxorubicin. MATERIALS & METHODS The cytotoxic effects of exoDOX were tested in vitro and in nude mice byExpand
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DNA Nanotechnology for Cancer Therapy
DNA nanotechnology is an emerging and exciting field, and represents a forefront frontier for the biomedical field. The specificity of the interactions between complementary base pairs makes DNA anExpand
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Structural Optimization of 4-Chlorobenzoylpiperidine Derivatives for the Development of Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors.
Monoacylglycerol lipase (MAGL) inhibitors are considered potential therapeutic agents for a variety of pathological conditions, including several types of cancer. Many MAGL inhibitors are reported inExpand
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The Clinical Translation of Organic Nanomaterials for Cancer Therapy: A Focus on Polymeric Nanoparticles, Micelles, Liposomes and Exosomes.
BACKGROUND The application of nanotechnology in the medical field is called nanomedicine. Nowadays, this new branch of science is a point of interest for many investigators due to the importantExpand
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Liposomal delivery of a Pin1 inhibitor complexed with cyclodextrins as new therapy for high‐grade serous ovarian cancer
ABSTRACT Pin1, a prolyl isomerase that sustains tumor progression, is overexpressed in different types of malignancies. Functional inactivation of Pin1 restrains tumor growth and leaves normal cellsExpand
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Bottom‐up synthesis of carbon nanoparticles with higher doxorubicin efficacy
Abstract Nanomedicine requires intelligent and non‐toxic nanomaterials for real clinical applications. Carbon materials possess interesting properties but with some limitations due to toxic effects.Expand
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Enhanced Chemotherapeutic Behavior of Open‐Caged DNA@Doxorubicin Nanostructures for Cancer Cells
In cancer therapy, it is imperative to increase the efficacy and reduce side effects of chemotherapeutic drugs. Nanotechnology offers the unique opportunity to overcome these barriers. In particular,Expand
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An Effective Multi-Stage Liposomal DNA Origami Nanosystem for In Vivo Cancer Therapy
DNA origami systems could be important candidates for clinical applications. Unfortunately, their intrinsic properties such as the activation of non-specific immune system responses leading toExpand
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