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Rescue of heavy metal effects on cell physiology of the algal model system Micrasterias by divalent ions
Recent studies have shown that metals such as copper, zinc, aluminum, cadmium, chromium, iron and lead cause severe dose-dependent disturbances in growth, morphogenesis, photosynthetic andExpand
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Three-dimensional organization of nascent rod outer segment disk membranes
Significance A vertebrate photoreceptor cell depends on the elaboration of its cilium to generate its light-sensitive organelle, the outer segment (OS), which is made up of a stack of membrane disks,Expand
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Defective phagosome motility and degradation in cell nonautonomous RPE pathogenesis of a dominant macular degeneration
Significance Cell nonautonomous toxicity is involved in various neurodegenerations, but mechanistic understanding is limited. Here, we provide insight into cellular mechanisms underlying a dominantExpand
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Microtubule motor transport in the delivery of melanosomes to the actin-rich apical domain of the retinal pigment epithelium
ABSTRACT Melanosomes are motile, light-absorbing organelles that are present in pigment cells of the skin and eye. It has been proposed that melanosome localization, in both skin melanocytes and theExpand
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A Comparison of Some Organizational Characteristics of the Mouse Central Retina and the Human Macula
Mouse models have greatly assisted our understanding of retinal degenerations. However, the mouse retina does not have a macula, leading to the question of whether the mouse is a relevant model forExpand
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Rapid differentiation of the human RPE cell line, ARPE-19, induced by nicotinamide.
Human RPE cell lines, especially the ARPE-19 cell line, are widely-used in eye research, as well as general epithelial cell studies. In comparison with primary RPE cells, they offer relativeExpand
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The route of the visual receptor rhodopsin along the cilium
ABSTRACT The photoreceptor outer segment is the most elaborate primary cilium, containing large amounts of rhodopsin (RHO) in disk membranes that grow from a connecting cilium. The movement of RHOExpand
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Multistep peripherin-2/rds self-assembly drives membrane curvature for outer segment disk architecture and photoreceptor viability
Significance Rod and cone photoreceptors are sensory neurons that underlie vertebrate vision. Rods and cones each use specialized membranous organelles, called outer segments (OSs), to transduceExpand
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Preservation of Photoreceptor Nanostructure for Electron Tomography Using Transcardiac Perfusion Followed by High-Pressure Freezing and Freeze-Substitution.
The phototransductive membrane disks of a vertebrate photoreceptor outer segment (OS) are highly susceptible to perturbations during preservation for electron microscopy. To optimize theirExpand
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Peroxisome turnover and diurnal modulation of antioxidant activity in retinal pigment epithelia utilizes microtubule-associated protein 1 light chain 3B.
The retinal pigment epithelium (RPE) supports the outer retina through essential roles in the retinoid cycle, nutrient supply, ion exchange and waste removal. Each day the RPE removes the oldest ~10%Expand
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