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A requirement for wild-type Ras isoforms in mutant KRas-driven signalling and transformation.
- Carolyn Bentley, Stefanie S Jurinka, +9 authors D. Stokoe
- Biology, Medicine
- The Biochemical journal
- 1 June 2013
The mutant forms of KRas, NRas and HRas drive the initiation and progression of a number of human cancers, but less is known about the role of WT (wild-type) Ras alleles and isoforms in cancer. We… Expand
Identification and Analysis of In Vivo VEGF Downstream Markers Link VEGF Pathway Activity with Efficacy of Anti-VEGF Therapies
Purpose: The aim of this study was to identify conserved pharmacodynamic and potential predictive biomarkers of response to anti-VEGF therapy using gene expression profiling in preclinical tumor… Expand