Stefanie Preuss

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Central nervous effects of the peptides cholecystokinin (CCK) and calcitonin (CT) were tested in an attention task for their effects on Auditory Event Related Potentials (AERPs) and for their effects on satiety and activation as measured in self-rating scales. Thirteen healthy subjects received either 3 IDU/kg bodyweight CCK 1-33, 0.1 IU/kg bodyweight CT(More)
Hypoxemic respiratory failure of the neonatal organism involves increased acid sphingomyelinase (aSMase) activity and production of ceramide, a second messenger of a pro-inflammatory pathway that promotes increased vascular permeability, surfactant alterations and alveolar epithelial apoptosis. We comparatively assessed the benefits of topical aSMase(More)
Elastin plays a pivotal role in lung development. We therefore queried if elastin haploinsufficient newborn mice (Eln(+/-)) would exhibit abnormal lung structure and function related to modified extracellular matrix (ECM) composition. Because mechanical ventilation (MV) has been linked to dysregulated elastic fiber formation in the newborn lung, we also(More)
BACKGROUND 18:1/18:1-Dioleoyl-phosphatidylgycerol (DOPG) is a surfactant phospholipid that is nearly non-detectable in neonatal surfactant films. When alveolar macrophages are exposed to DOPG in vitro, secretory phospholipase A2 (sPLA2) production is blocked, resulting in suppressed macrophage activity and improved surfactant function. We investigated(More)
D-myo-inositol-1,2,6-trisphosphate (IP3) is an isomer of the naturally occurring second messenger D-myo-inositol-1,4,5-trisphosphate, and exerts anti-inflammatory and antiedematous effects in the lung. Myo-inositol (Inos) is a component of IP3, and is thought to play an important role in the prevention of neonatal pulmonary diseases such as bronchopulmonary(More)
INTRODUCTION Testing the validity of the Mainz Pain Staging System (MPSS) is often carried out by pain classification according to chronic stage. It is assumed that pain syndromes distribute equally over the chronic stages. This analysis was carried out to answer three questions: Do different pain syndromes vary in chronicity, do the four axes of the MPSS(More)
Elafin is a potent reversible inhibitor of the pro-inflammatory proteases leukocyte elastase and protease 3. It is currently in clinical development for the use in postoperative inflammatory diseases. We investigated the pharmacokinetics of (99m)Tc-labeled elafin ((99m)Tc-Elafin) in blood and individual organs in rat after bolus intravenous injection using(More)
Considering that the number of malignant diseases in patients over 65 years of age is increasing, it often occurs that patients who carry a cardiac implanted electronic device must undergo radiotherapy. Ionizing radiation can disturb the function of the implantable cardioverter–defibrillator (ICD). As a result of this, an update of the DEGRO/DKG guidelines(More)
s of the 51st Workshop for Pediatric Research 51st Workshop for Pediatric Research<lb>Göttingen, Germany 16-17 April 2015<lb>This supplement has not been sponsored.<lb>Meeting abstracts<lb>Rationale<lb>Infants born prematurely or with intrauterine growth restriction (IUGR) are often afflicted with CLD, a debilitating<lb>disorder marked by diminished alveoli(More)
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