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Nonsense-mediated mRNA decay in human cells: mechanistic insights, functions beyond quality control and the double-life of NMD factors
- P. Nicholson, Hasmik Yepiskoposyan, Stefanie Metze, Rodolfo Zamudio Orozco, N. Kleinschmidt, O. Mühlemann
- Medicine, Biology
- Cellular and Molecular Life Sciences
- 27 February 2010
Nonsense-mediated decay is well known by the lucid definition of being a RNA surveillance mechanism that ensures the speedy degradation of mRNAs containing premature translation termination codons.… Expand
Comparison of EJC-enhanced and EJC-independent NMD in human cells reveals two partially redundant degradation pathways.
Nonsense-mediated mRNA decay (NMD) is a eukaryotic post-transcriptional gene regulation mechanism that eliminates mRNAs with the termination codon (TC) located in an unfavorable environment for… Expand
Investigation of aberrant vs. normal translation termination in HeLa extracts
Commonalities and differences between the EJC-enhanced and EJC-independent mode of NMD in human cells
Alternative pathways of nonsense-mediated mRNA decay
An imperial enlightenment? : notions of India and the literati of Edinburgh, 1723-1791
- Stefanie Metze
Analysis of (premature) stop codon recognition in HeLa translation extracts