Stefanie Krause

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Activation of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels is facilitated in vivo by direct binding of the second messenger cAMP. This process plays a fundamental role in the fine-tuning of HCN channel activity and is critical for the modulation of cardiac and neuronal rhythmicity. Here, we identify the pyrimidine cyclic nucleotide(More)
Pre-mRNAs for brain-expressed ionotropic glutamate receptor subunits undergo RNA editing by site-specific adenosine deamination, which alters codons for molecular determinants of channel function. This nuclear process requires double-stranded RNA structures formed by exonic and intronic sequences in the pre-mRNA and is likely to be catalyzed by an adenosine(More)
In this paper, we present the development and application of current image processing techniques to perform MRI inter-subject comparison of knee cartilage thickness based on the registration of bone structures. Each point in the bone surface which is part of the bone-cartilage interface is assigned a cartilage thickness value. Cartilage and corresponding(More)
Paramyosin isolated from the adductor muscle of Mercenaria mercenaria was shown to contain three to five phosphate groups/molecule; the actual number varied depending on the method used to extract the protein. Dephosphorylation resulted in an increase in the solubility of paramyosin near pH 7 and near physiological ionic strength. This behavior suggests(More)
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