Stefanie Krähenbühl

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Background:This analysis was initiated to define the predictive value of the area under the curve of high-dose methotrexate (AUCHD-MTX) in patients with primary central nervous system lymphoma (PCNSL).Patients and methods:We included 55 patients with PCNSL and available pharmacokinetic (PK) data from the International Extranodal Lymphoma Study Group (IELSG)(More)
INTRODUCTION We found that pulse pressure variation (PPV) did not predict volume responsiveness in patients with increased pulmonary artery pressure. This study tests the hypothesis that PPV does not predict fluid responsiveness during an endotoxin-induced acute increase in pulmonary artery pressure and right ventricular loading. METHODS Pigs were(More)
BACKGROUND Although they appear more rarely than electrolyte disturbances, cutaneous reactions are important adverse effects of furosemide. This is particularly true for bullous skin eruptions, because they may be life-threatening. CASE REPORT We describe a patient who developed acute generalized exanthematic pustulosis (AGEP) during treatment with(More)
We report a 36-year-old woman who slowly developed an ulceration on the left thigh 2 years after transplantation for Budd-Chiari syndrome. At this time point, the patient was treated with prednisone, tacrolimus and azathioprine for immunosuppression and with phenprocoumon and low-dose aspirin for anticoagulation in the presence of polycythemia vera. A(More)
OBJECTIVES Controversy exists about the integration of erlotinib in patients with EGFR wildtype, advanced NSCLC. MATERIALS AND METHODS We included patients with advanced NSCLC receiving at least two lines of palliative systemic treatment between January 2005 and December 2014 and not harbouring targetable driver mutations. Primary study endpoint was(More)
study started in January 2012 and included pts who started treatment with gefitinib prior to study entry or at study entry (referred to as ‘new pts’). Efficacy, safety and quality of life with gefitinib were assessed over a two-year follow up period. Results: A total of 361 pts were recruited across 104 sites up to March 2013, including 116 (32%) ‘new’ pts.(More)
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