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Hematopoiesis in general is demand driven and adaptive, but in contrast to erythropoiesis or thrombocytopoiesis, our knowledge on how neutrophil production is adapted to individual needs remains incomplete. Recently, neutrophil homeostasis has been shown to depend on danger receptors, macrophages, and even circadian rhythms. Puzzle pieces for a broader view(More)
Polymorphonuclear neutrophil granu-locytes (neutrophils) represent a fundamental component of the innate immune system, forming an efficient barrier against invading microbial pathogens. Neutropenia, a common unwanted side effect of chemotherapy, is associated with infectious complications. The human bone marrow produces an estimated number of 10 11(More)
While paraneoplastic leukocytosis is a common phenomenon in solid tumors, extreme elevations of white blood counts (WBC) in the range of more than 100,000/μl are uncommon in patients with non-hematologic malignancies. Leukocytosis with mature neutrophils due to a granulocyte colony-stimulating factor (G-CSF) producing tumor is only seen on rare occasions.(More)
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