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The effects of d-fenfluramine and morphine on various nociceptive responses of rats were investigated. Unlike morphine, which inhibited all the responses examined, d-fenfluramine inhibited jumping and paw licking of rats on a hot plate, but did not increase the latency of tail withdrawal from hot water. The effects of d-fenfluramine on both responses on the(More)
Various drugs acting on brain serotonin or catecholamines were administered concurrently with morphine during the development of dependence or before naloxone-precipitated withdrawal syndrome. Of the various drugs only cyproheptadine, a serotonin antagonist, and piribedil, a dopamine agonist, reduced the frequency of jumping (but not of diarrhea or ptosis)(More)
The regional brain metabolism of serotonin (5-HT) and dopamine (DA) was studied in rats injected with morphine either systemically or in the nuclei raphe medianus (MR) or dorsalis (DR). A subcutaneous injection of 10 mg/kg morphine significantly raised the levels of 5-hydroxyindoleacetic acid (5-HIAA) in the diencephalon, striatum, nucleus accumbens and(More)
Several monofloral Cuban honeys were analyzed to determine their total phenolic, flavonoid, ascorbic acid, amino acid, protein and carotenoid contents as well as their radical-scavenging activity and antimicrobial capacities. The total phenolic, flavonoid and carotenoid contents varied considerably, and the highest values were obtained for Linen vine(More)
The strawberry (Fragaria X ananassa, Duch.) represents a relevant source of micronutrients, such as minerals, vitamin C, folate and phenolic substances, most of which are natural antioxidants and contribute to the high nutritional quality of the fruit. All these compounds are essential for health and, in particular, strawberry phenolics are best known for(More)
A withdrawal syndrome was precipitated by naloxone in morphine-dependent rats injected with 5,7-dihydroxytryptamine (5,7-DHT) in the ventromedial tegmentum (VMT) at the level of the nucleus interpeduncularis. 5,7-DHT, which markedly depleted 5-hydroxytryptamine (5-HT) in the forebrain but not in the brainstem, significantly reduced jumping in abstinent rats(More)
(+)-Fenfluramine, a 5-hydroxytryptamine (5-HT) releaser and uptake blocker, m-chlorophenylpiperazine (CPP), a 5-HT receptor agonist, and clonidine, an agonist at adrenoceptors, were studied for their ability to modify jumping and wet dog shakes in morphine abstinent rats. (+)-Fenfluramine and CPP blocked jumping with no effect on wet dog shakes whereas the(More)
The involvement of brain monoamines in the mechanism of action of nefopam, a new analgesic, was investigated in rats. The study was designed to evaluate the effect of various means of impairing monoaminergic transmission on nefopam analgesia as measured with the hot plate method. Pretreatment with reserpine (2 mg/kg) significantly reduced the(More)
The possibility that serotoninergic mechanisms control the reinforcing properties of d-amphetamine and morphine was investigated in rats, using zimelidine, a potent and selective serotonin uptake blocker and the conditioned place preference test design. Zimelidine dihydrochloride 20 mg/kg did not cause place aversion and did not modify the place preference(More)