Stefan Wolfsberger

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Surgical approaches tailored to an individual patient's anatomy and pathology have become standard in neurosurgery. Precise preoperative planning of these procedures, however, is necessary to achieve an optimal therapeutic effect. Therefore, multiple radiological imaging modalities are used prior to surgery to delineate the patient's anatomy, neurological(More)
Histopathologic grading of ependymomas is considered unreliable in terms of outcome prediction. Quantification of tumor cell proliferation may be useful for outcome prediction. We analyzed prognostic and predictive values of tumor cell proliferation rates using anti-Ki-67 antigen (MIB-1 antibody) and anti-topoisomerase-IIalpha (Topo-IIalpha) immunolabeling(More)
OBJECTIVE To analyze the effect of prone position on cerebral perfusion pressure and brain tissue oxygen partial pressure in subarachnoid hemorrhage patients with acute respiratory distress syndrome (ARDS). DESIGN Clinical study with retrospective data analysis. SETTING Neurosurgical intensive care unit of a primary level university hospital. PATIENTS(More)
Endonasal transsphenoidal pituitary surgery is a minimally invasive endoscopic procedure, applied to remove various kinds of pituitary tumors. To reduce the risk associated with this treatment, the surgeon must be skilled and well-prepared. Virtual endoscopy can be beneficial as a tool for training, preoperative planning and intraoperative support. This(More)
OBJECT The aim of this study was to determine the value of high-field magnetic resonance (MR) imaging for diagnosis and surgery of sellar lesions. METHODS High-field MR images were obtained using a 3-tesla unit with emphasis on sellar and parasellar structures in 21 patients preoperatively to delineate endo-, supra-, and parasellar anatomical structures.(More)
For recurrent and untreatable meningiomas alternative therapies, such as anti-progesterone treatment, have been sought. However, the few clinical studies have not determined progesterone receptor (PgR) expression in most cases, and studies correlating quantitative PgR expression (PgR index) with clinico-pathological variables are scarce. The aim of our(More)
BACKGROUND Precise lesion localization is necessary for neurosurgical procedures not only during the operative approach, but also during the preoperative planning phase. OBJECTIVE To evaluate the advantages of 3-dimensional (3-D) brain surface visualization over conventional 2-dimensional (2-D) magnetic resonance images for surgical planning and(More)
We investigated angiogenic patterns and expression of hypoxia-related tissue factors and their prognostic impact in 100 cases of intracranial ependymoma. Angiogenic patterns were evaluated by anti-CD34 immunolabeling. Hypoxia-related factors carbonic anhydrase 9 (CA9) and hypoxia-inducible factor 1 alpha (HIF-1α) were visualized by immunohistochemistry, and(More)
Endoscopy has recently been introduced to endonasal transsphenoidal pituitary surgery as a minimally invasive procedure for the removal of various kinds of pituitary tumors. To reduce morbidity and mortality with this new technique, the surgeon must be well-trained and well-prepared. Virtual endoscopy can be beneficial as a tool for training, preoperative(More)