Stefan Störk

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OBJECTIVE The long-term effects of enzyme-replacement therapy (ERT) in Fabry disease are unknown. Thus, the aim of this study was to determine whether ERT in patients with advanced Fabry disease affects progression towards 'hard' clinical end-points in comparison with the natural course of the disease. METHODS A total of 40 patients with genetically(More)
OBJECTIVES The aim of this study was to explore the left ventricular (LV) deformation changes and the potential impact of deformation on outcome in patients with proven light-chain (AL) amyloidosis and LV hypertrophy. BACKGROUND Cardiac involvement in AL amyloidosis patients is associated with poor outcome. Detecting regional cardiac function by advanced(More)
INTRODUCTION Experimental data indicates an important role of the innate immune system in cardiac remodeling and heart failure (HF). Complement is a central effector pathway of the innate immune system. Animals lacking parts of the complement system are protected from adverse remodeling. Based on these data, we hypothesized that peripheral complement levels(More)
Electronic health records are a rich source for medical information. However, large parts of clinical diagnosis reports are in textual form and are therefore not per se usable for statistical evaluations. To transform the information from an unstructured into a struc-tured form is the goal of medical language processing. In this paper we want to propose an(More)
For epidemiological research, the usage of standard electronic health records may be regarded a convenient way to obtain large amounts of medical data. Unfortunately, large parts of clinical reports are in written text form and cannot be used for statistical evaluations without appropriate preprocessing. This functionality is one of the main tasks in(More)
OBJECTIVES Since diastolic abnormalities are typical findings of cardiac amyloidosis (CA), we hypothesized that speckle-tracking-imaging (STI) derived longitudinal early diastolic strain rate (LSRdias) could predict outcome in CA patients with preserved left ventricular ejection fraction (LVEF >50%). BACKGROUND Diastolic abnormalities including altered(More)
OBJECTIVES Population-based health risk assessment and stratification are considered highly relevant for large-scale implementation of integrated care by facilitating services design and case identification. The principal objective of the study was to analyse five health-risk assessment strategies and health indicators used in the five regions participating(More)
BACKGROUND Information extraction techniques that get structured representations out of unstructured data make a large amount of clinically relevant information about patients accessible for semantic applications. These methods typically rely on standardized terminologies that guide this process. Many languages and clinical domains, however, lack(More)
BACKGROUND To assess heart failure therapies in diabetic patients with preserved as compared to impaired systolic ventricular function. METHODS 3304 patients with heart failure from 9 different studies were included (mean age 63 ± 14 years); out of these, 711 subjects had preserved left ventricular ejection fraction (≥ 50%) and 994 patients in the whole(More)
BACKGROUND High-sensitivity troponin (hs-TNT), a biomarker of myocardial damage, might be useful for assessing fibrosis in Fabry cardiomyopathy. We performed a prospective analysis of hs-TNT as a biomarker for myocardial changes in Fabry patients and a retrospective longitudinal follow-up study to assess longitudinal hs-TNT changes relative to fibrosis and(More)