Stefan Schäfer

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BACKGROUND AND PURPOSE In endothelial dysfunction, signalling by nitric oxide (NO) is impaired because of the oxidation and subsequent loss of the soluble guanylyl cyclase (sGC) haem. The sGC activator 4-[((4-carboxybutyl){2-[(4-phenethylbenzyl)oxy]phenethyl}amino)methyl[benzoic]acid (BAY 58-2667) is a haem-mimetic able to bind with high affinity to sGC(More)
Guaranteeing that the worst-case scenario has been covered for each basic block individually is a major challenge in measurement-based WCET analysis. On the static analysis side the accuracy of hardware models used are also subject to doubt as they are based on available documentation provided by vendors which may be not detailed enough nor correct or both.(More)
Instruction selection is a compiler optimisation that translates the intermediate representation of a program into a lower intermediate representation or an assembler program. We use the SSA form as an intermediate representation for instruction selection. Patterns are used for translation and are expressed as production rules in a graph grammar. The(More)
Human neutrophil elastase (HNE) is a key protease for matrix degradation. High HNE activity is observed in inflammatory diseases. Accordingly, HNE is a potential target for the treatment of pulmonary diseases such as chronic obstructive pulmonary disease (COPD), acute lung injury (ALI), acute respiratory distress syndrome (ARDS), bronchiectasis (BE), and(More)
OBJECTIVE C-reactive protein (CRP) is the prototype acute phase protein and a cardiovascular risk factor. Interleukin-1beta (IL-1beta) and IL-6 stimulate CRP synthesis in hepatocytes. We searched for additional pathways regulating CRP expression. METHODS AND RESULTS Primary human hepatocytes (PHHs) were treated with IL-1beta, IL-6, and protein kinase C(More)
Today's most challenging application of computer graphics is the rendering of real scale scenes at photorealistic quality. As this task needs a lot of computing resources, numerous techniques have been applied to speed up rendering, one of these being parallel processing. This paper presents our approach to the efficient parallelization of different(More)