• Publications
  • Influence
Beta-caryophyllene is a dietary cannabinoid
The psychoactive cannabinoids from Cannabis sativa L. and the arachidonic acid-derived endocannabinoids are nonselective natural ligands for cannabinoid receptor type 1 (CB1) and CB2 receptors.Expand
  • 488
  • 31
  • PDF
Alkylamides from Echinacea Are a New Class of Cannabinomimetics
Alkylamides (alkamides) from Echinacea modulate tumor necrosis factor α mRNA expression in human monocytes/macrophages via the cannabinoid type 2 (CB2) receptor (Gertsch, J., Schoop, R., Kuenzle, U.,Expand
  • 207
  • 12
  • PDF
Synergistic immunomopharmacological effects of N-alkylamides in Echinacea purpurea herbal extracts.
Echinacea purpurea extracts are used in the production of standardized herbal medicines for the prevention and treatment of upper respiratory infections. Unsaturated N-alkylamide lipids, the mainExpand
  • 69
  • 4
In silico target fishing for rationalized ligand discovery exemplified on constituents of Ruta graveolens.
The identification of targets whose interaction is likely to result in the successful treatment of a disease is of growing interest for natural product scientists. In the current study we performedExpand
  • 111
  • 3
Falcarinol is a covalent cannabinoid CB1 receptor antagonist and induces pro-allergic effects in skin.
The skin irritant polyyne falcarinol (panaxynol, carotatoxin) is found in carrots, parsley, celery, and in the medicinal plant Panax ginseng. In our ongoing search for new cannabinoid (CB) receptorExpand
  • 75
  • 3
Mechanisms of osteoclastogenesis inhibition by a novel class of biphenyl-type cannabinoid CB(2) receptor inverse agonists.
The cannabinoid CB(2) receptor is known to modulate osteoclast function by poorly understood mechanisms. Here, we report that the natural biphenyl neolignan 4'-O-methylhonokiol (MH) is a CB(2)Expand
  • 56
  • 2
New Natural Noncannabinoid Ligands for Cannabinoid Type-2 (CB2) Receptors
Since the discovery that Δ 9-tetrahydrocannabinol and related cannabinoids from Cannabis sativa L. act on specific physiological receptors in the human body and the subsequent elucidation of theExpand
  • 37
  • 2
Self-assembling cannabinomimetics: supramolecular structures of N-alkyl amides.
Certain fatty acid N-alkyl amides from the medicinal plant Echinacea activate cannabinoid type-2 (CB2) receptors. In this study we show that the CB2-binding Echinacea constituentsExpand
  • 10
  • 1
  • PDF
Self-assembling cannabinomimetics: supramolecular structures of N-alkyl amides.
Certain fatty acid N-alkyl amides from the medicinal plant Echinacea activate cannabinoid type-2 (CB2) receptors. In this study we show that the CB2-binding Echinacea constituentsExpand
  • 9
  • 1