Stefan R. Lange

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Adjusting for multiple testing--when and how?

Ralf Bender, Stefan R. Lange
Journal of clinical epidemiology
2001

Multiplicity of data, hypotheses, and analyses is a common problem in biomedical and epidemiological research. Multiple testing theory provides a framework for defining and controlling appropriate… (More)

High prevalence of peripheral arterial disease and co-morbidity in 6880 primary care patients: cross-sectional study.

Curt Diehm, Alexander Schuster, +7 authors Hans Joachim Trampisch
Atherosclerosis
2004

We aimed to obtain reliable data on the epidemiology, co-morbidities and risk factor profile of peripheral arterial disease (PAD) in general medical practise. In the cross-sectional part of the… (More)

Association of low ankle brachial index with high mortality in primary care.

Curt Diehm, Stefan R. Lange, +7 authors Hans Joachim Trampisch
European heart journal
2006

AIMS We aimed to assess the increased risk of death and severe vascular events in elderly individuals with subclinical or manifest peripheral arterial disease (PAD), evidenced by low ankle brachial… (More)

Comparison of leg compression stocking and oral horse-chestnut seed extract therapy in patients with chronic venous insufficiency

Curt Diehm, Hans Joachim Trampisch, Stefan R. Lange, Christina Schmidt
The Lancet
1996

BACKGROUND Diseases of the venous system are widespread disorders sometimes associated with modern civilisation and are among the major concerns of social and occupational medicine. This study was… (More)

Multiple test procedures other than Bonferroni's deserve wider use.

Excess 1-year cardiovascular risk in elderly primary care patients with a low ankle-brachial index (ABI) and high homocysteine level.

Stefan R. Lange, Hans Joachim Trampisch, +7 authors Curt Diehm
Atherosclerosis
2005

Previous studies in selected patient samples suggested a high risk for total mortality and cardiovascular (CV) morbidity associated not only with symptomatic, but also with asymptomatic peripheral… (More)

Permanent interstitial low-dose-rate brachytherapy for patients with localised prostate cancer: a systematic review of randomised and nonrandomised controlled clinical trials.

Frank Peinemann, Ulrich Grouven, +5 authors Stefan R. Lange
European urology
2011

CONTEXT Prostate cancer (PCa) is the most common cancer in men. Permanent interstitial low-dose-rate brachytherapy (LDR-BT) is a short-distance radiation therapy in which low-energy radioactive… (More)

Randomized controlled trials on PET: a systematic review of topics, design, and quality.

Fülöp J Scheibler, Polina Zumbé, +6 authors Stefan R. Lange
Journal of nuclear medicine : official…
2012

UNLABELLED Randomized controlled trials (RCTs) add important information to diagnostic accuracy studies in the evaluation of PET and PET/CT. We evaluated how many RCTs on PET existed, which clinical… (More)

The Range and Scientific Value of Randomized Trials.

Stefan R. Lange, Stefan Sauerland, Joerg Lauterberg, J. Windeler
Deutsches Arzteblatt international
2017

BACKGROUND The randomized, controlled trial (RCT) is the gold standard of scientific evidence for the attribution of clinical effects (benefits and harms) to medical interventions. Many different… (More)

Attention should be given to multiplicity issues in systematic reviews.

Ralf Bender, Catey Bunce, +4 authors Kristian Thorlund
Journal of clinical epidemiology
2008

OBJECTIVE The objective of this paper is to describe the problem of multiple comparisons in systematic reviews and to provide some guidelines on how to deal with it in practice. STUDY DESIGN AND… (More)

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