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An important goal for digital libraries is to enable researchers to more easily explore related work. While citation data is often used as an indicator of relatedness, in this paper we demonstrate that digital access records (e.g. http-server logs) can be used as indicators as well. In particular, we show that measures based on co-access provide better(More)
Clinical systematic reviews are based on expert, laborious search of well-annotated literature. Boolean search on bibliographic databases, such as MEDLINE, continues to be the preferred discovery method, but the size of these databases, now approaching 20 million records, makes it impossible to fully trust these searching methods. We are investigating the(More)
The analysis of many natural glycoproteins and their recombinant counterparts from mammalian hosts has revealed that the basic oligosaccharide structures and the site occupancy of glycosylated polypeptides are primarily dictated by the protein conformation. The equipment of many frequently used host cells (e.g. BHK-21 and CHO-cells) with(More)
Human beta-trace protein is a major intrathecally synthesized polypeptide constituent of human cerebrospinal fluid. We have previously shown that this protein is almost quantitatively modified with biantennary complex-type N-linked oligosaccharides which show "brain-type" glycosylation characteristics (Hoffmann,A. et al., J. Neurochem., 63, pp. 2185-2191,(More)
Searching for relevant documents is a laborious task involved in preparing systematic reviews of biomedical literature. Currently, complex Boolean queries are iteratively developed, and then each document of the final query result is assessed for relevance. However, the result set sizes of these queries are hard to control, and in practice it is difficult(More)
BACKGROUND The process of constructing a systematic review, a document that compiles the published evidence pertaining to a specified medical topic, is intensely time-consuming, often taking a team of researchers over a year, with the identification of relevant published research comprising a substantial portion of the effort. The standard paradigm for this(More)
Extended Boolean retrieval (EBR) models were proposed nearly three decades ago, but have had little practical impact, despite their significant advantages compared to either ranked keyword or pure Boolean retrieval. In particular, EBR models produce meaningful rankings; their query model allows the representation of complex concepts in an and-or format; and(More)