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Although the scientific literature contains numerous reports of the statistical accuracy of systems for self-monitoring of blood glucose (SMBG), most of these studies determine accuracy in ways that may not be clinically useful. We have developed an error grid analysis (EGA), which describes the clinical accuracy of SMBG systems over the entire range of(More)
Although it is well established that fish possess corticotropin-releasing factor (CRF) and a CRF-like peptide, urotensin I, comparatively little is known about the pharmacology of their cognate receptors. Here we report the isolation and functional expression of two complementary DNAs (cDNAs), from the chum salmon Oncorhynchus keta, which encode orthologues(More)
Type I (insulin-dependent) diabetic individuals and health professionals often assume that the symptoms of extremely low or high blood glucose (BG) levels can be recognized and, consequently, appropriate treatment decisions can be based on symptom perception. Because no research has documented the validity of these assumptions, this study tested the ability(More)
An important goal for digital libraries is to enable researchers to more easily explore related work. While citation data is often used as an indicator of relatedness, in this paper we demonstrate that digital access records (e.g. http-server logs) can be used as indicators as well. In particular, we show that measures based on co-access provide better(More)
Clinical systematic reviews are based on expert, laborious search of well-annotated literature. Boolean search on bibliographic databases, such as MEDLINE, continues to be the preferred discovery method, but the size of these databases, now approaching 20 million records, makes it impossible to fully trust these searching methods. We are investigating the(More)
This thesis investigates in the use of access log data as a source of information for identifying related scientific papers. This is done for arXiv.org, the authority for publication of e-prints in several fields of physics. Compared to citation information, access logs have the advantage of being immediately available, without manual or automatic(More)
Thirty hospitalized diabetics completed symptom checklists immediately prior to monitoring their own blood glucose level seven times a day for 6--10 days. For each subject, simple correlations were computed between each of the physical symptoms and blood glucose level. Most subjects evidenced several symptoms that were highly correlated with glucose(More)
The ability of psyllium fiber to reduce postprandial serum glucose and insulin concentrations was studied in 18 non-insulin-dependent diabetic patients in a crossover design. Psyllium fiber or placebo was administered twice during each 15-h crossover phase, immediately before breakfast and dinner. No psyllium fiber or placebo was given at lunch, which(More)
Self-management of insulin-dependent diabetes mellitus (IDDM) is dependent on a negative feedback loop of blood glucose (BG) fluctuations, which in turn directs treatment decisions to maintain normal BG. Although this feedback is typically accomplished by self-monitoring of blood glucose (SMBG), SMBG has limitations, and patients often rely on what their BG(More)
BACKGROUND The process of constructing a systematic review, a document that compiles the published evidence pertaining to a specified medical topic, is intensely time-consuming, often taking a team of researchers over a year, with the identification of relevant published research comprising a substantial portion of the effort. The standard paradigm for this(More)