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  • Stefan O. Mueller, Stéphanie Simon, Kun Chae, Manfred Metzler, Kenneth S. Korach
  • Medicine
  • Toxicological sciences : an official journal of…
  • 2004
  • Phytoestrogens exert pleiotropic effects on cellular signaling and show some beneficial effects on estrogen-dependent diseases. However, due to activation/inhibition of the estrogen receptors ERalphaContinue Reading
  • Stefan O. Mueller, Stéphanie Simon, Kun Chae, Manfred Metzler, Kenneth S. Korach
  • Biology
  • 2004 (First Published: 10 March 2004)
  • Phytoestrogens exert pleiotropic effects on cellular signaling and show some beneficial effects on estrogen-dependent diseases. However, due to activation/inhibition of the estrogen receptors ERa orContinue Reading
  • Manuel Ammerschlaeger, Juergen Beigel, Kai-Uwe Klein, Stefan O. Mueller
  • Biology, Medicine
  • Toxicological sciences : an official journal of…
  • 2004 (First Published: 21 January 2004)
  • Peroxisome proliferation is a well-defined pleiotropic effect that is mediated by the ligand inducible transcription factor peroxisome proliferator-activated receptor (PPAR) alpha. Because markedContinue Reading
  • Anja Wilmes, Alice Limonciel, +24 authors Paul Jennings
  • Biology, Medicine
  • Journal of proteomics
  • 2013 (First Published: 1 February 2013)
  • High content omic techniques in combination with stable human in vitro cell culture systems have the potential to improve on current pre-clinical safety regimes by providing detailed mechanisticContinue Reading
  • Patrício Godoy, Jan G. Hengstler, +6 authors Steven Dooley
  • Biology, Medicine
  • Hepatology
  • 2009 (First Published: 1 June 2009)
  • UNLABELLED Hepatocytes in culture are a valuable tool to investigate mechanisms involved in the response of the liver to cytokines. However, it is well established that hepatocytes cultured onContinue Reading
  • Gregor Tuschl, Jens Hrach, Yvonne Walter, Philip G. Hewitt, Stefan O. Mueller
  • Chemistry, Medicine
  • Chemico-biological interactions
  • 2009 (First Published: 1 September 2009)
  • Cultures of primary hepatocytes from various species, including human, are used in several applications during pre-clinical drug development. Their use is however limited by cell survival andContinue Reading