Stefan Muller

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The inducible transcriptional complex AP-1, composed of c-Fos and c-Jun proteins, is crucial for cell adaptation to many environmental changes. While its mechanisms of activation have been extensively studied, how its activity is restrained is poorly understood. We report here that lysine 265 of c-Fos is conjugated by the peptidic posttranslational(More)
In contrast to protein antigens, processing of glycoproteins by dendritic cells (DCs) for presentation to T cells has not been well studied. We developed mouse T cell hybridomas to study processing and presentation of the tumor antigen MUC1 as a model glycoprotein. MUC1 is expressed on the surface as well as secreted by human adenocarcinomas. Circulating(More)
Aggregation patterns of the slime mould Dictyostelium discoideum were recorded using dark-field equipment combined with video techniques. Computerized image processing allowed the analysis of wave collision structures , expanding concentric circles and rotating spirals in terms of wave velocity and front geometry, as previously done in the(More)
Cellular signaling pathways largely depend on the plasticity of multiprotein complexes. A central mechanism that assures the coordinated assembly and disassembly of protein complexes is the reversible post-translational modification of the individual components for example by phosphorylation, acetylation, or ubiquitylation. Accumulating evidence indicates(More)
Visual biofeedback with information about the patients' degree of activity is a valuable adjunct to robot-assisted gait training as means of increasing the motivation and participation of the patients during highly repetitive training sessions. In the driven gait orthosis (DGO) Lokomat, an estimation of the patient's activity level was based on man-machine(More)
A class of stored energy densities that includes functions of the form W (F) = a j F j p + g (F ; adj F) + h (det F) with a > 0, g and h convex and smooth, and 2 < p < 3 is considered. The main result shows that for each such W in this class there is a k > 0 such that, if a 3 b y 3 matrix F 0 satises h 0 (det F 0)jF 0 j 3p k, then W is W 1;p-quasiconvex at(More)
There is currently no standardized approach for parsing output that the numerous bioinformatical tools generate. Because the framework approach of the Bio-toolkits has some shortcomings, we searched for alternative approaches. To this end, we evaluated scanner generators for various programming languages with respect to their potential of standalone, small(More)