Stefan Mitterreiter

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The two proteases beta-secretase and gamma-secretase generate the amyloid beta peptide and are drug targets for Alzheimer's disease. Here we tested the possibility of targeting the cellular environment of beta-secretase cleavage instead of the beta-secretase enzyme itself. beta-Secretase has an acidic pH optimum and cleaves the amyloid precursor protein in(More)
ADAM proteases are type I transmembrane proteins with extracellular metalloprotease domains. As for most ADAM family members, ADAM8 (CD156a, MS2) is involved in ectodomain shedding of membrane proteins and is linked to inflammation and neurodegeneration. To identify potential substrates released under these pathologic conditions, we screened 10-mer peptides(More)
The link between cholesterol and Alzheimer's disease has recently been revealed in Niemann-Pick type C disease. We found that NPC1(-/-) cells show decreased expression of APP at the cell surface and increased processing of APP through the beta-secretase pathway resulting in increased C99, sAPPbeta and intracellular Abeta40 levels. This effect is dependent(More)
Stefan Mitterreiter,1 Richard M. Page,1 Frits Kamp,1 Jessika Hopson,2 Edith Winkler,1 Huy-Riem Ha,3 Runa Hamid,4 Jochen Herms,4 Thomas U. Mayer,5 Deborah J. Nelson,2 Harald Steiner,1 Tobias Stahl,6 Ulrike Zeitschel,7 Steffen Roßner,7 Christian Haass,1 and Stefan F. Lichtenthaler1 1German Center for Neurodegenerative Diseases Munich and Adolf(More)
ADAM proteases are type I transmembrane proteins with extracellular metalloprotease domains. Like most ADAM family members, ADAM8 (CD156a, MS2) is involved in ectodomain shedding of membrane proteins and is linked to neuroinflammation and neurodegeneration. To identify potential substrates released under these pathologic conditions, we screened 10-mer(More)
Prion diseases are a group of lethal neurodegenerative disorders associated with misfolding of a host protein, the prion protein PrP. But despite increasing knowledges concerning this class of disease, up to now no therapeutic approach has been found to cure the disease or stabilize the pathogenesis in humans. A variety of potential therapeutic compounds(More)
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