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I/O Brush is our ongoing effort to empower people to create new expressions and meanings by painting with attributes of everyday objects and movements in their physical world. Using examples from our case studies with kindergarteners and artists, we discuss I/O Brush's most distinguishing features, its dynamic ink and history functions, and how they enable(More)
Interferon alpha-2a plays an essential role in the treatment of chronic hepatitis C, but it is limited in its efficacy by the short in vivo half-life. To improve the half-life and efficacy, interferon alpha-2a is conjugated with a 40-kDa branched polyethylene glycol moiety (PEG-IFN, PEGASYS). From this preparation the positional PEG-IFN isomers were(More)
OBJECTIVE To document cognition and behavior at school entry in these patients. Study design Eighteen children with congenital hypothyroidism (CH; 9 severe and 9 moderate, based on a surface of the knee epiphyses at diagnosis<or >or=0.05 cm(2)) treated from a median of 14 days with a median of 12.0 microg/kg per day of levothyroxine were evaluated at 5(More)
"The World as your Palette" is our ongoing effort to design and develop tools to allow artists to create visual art projects with elements (specifically, the color, texture, and moving patterns) extracted directly from their personal objects and their immediate environment. Our tool called "I/O Brush" looks like a regular physical paintbrush, but contains a(More)
Sawhney By " everywhere messaging " we refer to the ability to send and receive electronic communication at any time and through a variety of means, including wired and wireless computer networks, voice telephones, and pagers. Our goal is to design messaging systems in which the receiver is always " on " and available, and messages are correctly chosen for(More)
We present a system in which a cell phone decides whether to ring by accepting votes from the others in a conversation with the called party. When a call comes in, the phone first determines who is in the conversation by using a decentralized network of autonomous body-worn sensor nodes. It then vibrates all participants' wireless finger rings. Although the(More)
The present study was conducted to assess the usefulness of adding the multiplex nested-polymerase chain reaction assay of cerebrospinal fluid samples to routine diagnostic testing for herpesvirus encephalitis and to monitor the efficacy of therapy. Cerebrospinal fluid samples from 45 patients with presumed herpesvirus encephalitis were tested for herpes(More)
Antibody-dependent cellular cytotoxicity (ADCC) contributes to clinical efficacy of a broad range of antibody therapeutics. However, reproducible quantitation of ADCC activity on a cellular level remains highly challenging, as ADCC assays rely on primary effector cells associated with laborious cell purification procedures, resulting in highly(More)